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Title: Cortical gray matter reduction precedes transition to psychosis in individuals at clinical high-risk for psychosis: A voxel-based meta-analysis
Author: Fortea, Adriana
Batalla, Albert
Radua, Joaquim
van Eijndhoven, Philip
Baeza, Inmaculada, 1970-
Albajes Eizagirre, Anton
Fusar-Poli, Paolo
Castro Fornieles, Josefina
Serna, Elena de la
Luna, Licia P.
Carvalho, André F.
Vieta i Pascual, Eduard, 1963-
Sugranyes, Gisela
Keywords: Psicosi
Factors de risc en les malalties
Neuropsicologia clínica
Escorça cerebral
Risk factors in diseases
Clinical neuropsychology
Cerebral cortex
Issue Date: 2021
Publisher: Elsevier B.V.
Abstract: Gray matter and cortical thickness reductions have been documented in individuals at clinical high-risk for psychosis and may be more pronounced in those who transition to psychosis. However, these findings rely on small samples and are inconsistent across studies. In this review and meta-analysis we aimed to investigate neuroanatomical correlates of clinical high-risk for psychosis and potential predictors of transition, using a novel metaanalytic method (Seed-based d Mapping with Permutation of Subject Images) and cortical mask, combining data from surface-based and voxel-based morphometry studies. Individuals at clinical high-risk for psychosis who later transitioned to psychosis were compared to those who did not and to controls, and included three statistical maps. Overall, individuals at clinical high-risk for psychosis did not differ from controls, however, within the clinical high-risk for psychosis group, transition to psychosis was associated with less cortical gray matter in the right temporal lobe (Hedges' g = −0.377), anterior cingulate and paracingulate (Hedges' g = −0.391). These findings have the potential to help refine prognostic and etiopathological research in early psychosi
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It is part of: Schizophrenia Research, 2021, vol. 232, p. 98-106
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ISSN: 0920-9964
Appears in Collections:Articles publicats en revistes (Institut de Neurociències (UBNeuro))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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