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http://hdl.handle.net/2445/184378
Title: | Advantages of plasmatic CXCL-10 as a prognostic and diagnostic biomarker for the risk of rejection and subclinical rejection in kidney transplantation |
Author: | Millán, Olga Rovira, Jordi Guirado, Lluis Espinosa, Cristina Budde, Klemens Sommerer, Claudia Piñeiro, Gaston J. Diekmann, Fritz Brunet i Serra, Mercè |
Keywords: | Trasplantament renal Pronòstic mèdic Rebuig (Biologia) Kidney transplantation Prognosis Graft rejection |
Issue Date: | 3-Jul-2021 |
Publisher: | Elsevier B.V. |
Abstract: | This study evaluate the potential of plasmatic CXCL-10 (pCXCL-10) as a pre&post transplantation prognostic and diagnostic biomarker of T-cell-mediated rejection (TCMR), antibody-mediated rejection (ABMR) and subclinical rejection (SCR) risk in adult kidney recipients considering BKV and CMV infections as possible clinical confounder factors. Twenty-eight of 100 patients included experienced rejection (TCMR:14; ABMR:14); 8 SCR; 13 and 16 were diagnosed with BKV and CMV infection, respectively. Pre-transplantation pCXCL-10 was significantly increased in TCMR and ABMR and post-transplantation in TCMR, ABMR and SCR compared with nonrejectors. All CMV+ patients showed pCXCL-10 levels above the cutoff values established for rejection whereas the 80% of BKV+ patients showed pCXCL-10 concentration < 100 pg/mL. pCXCL-10 could improve pre-transplantation patient stratification and immunosuppressive treatment selection according to rejection risk; and after kidney transplantation could be a potential early prognostic biomarker for rejection. Clinical confounding factor in BKV+ and particularly in CMV+ patients must be discarded. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.clim.2021.108792 |
It is part of: | Clinical Immunology, 2021, vol. 2029, num. 108792 |
URI: | http://hdl.handle.net/2445/184378 |
Related resource: | https://doi.org/10.1016/j.clim.2021.108792 |
ISSN: | 1521-6616 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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