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http://hdl.handle.net/2445/184407
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DC Field | Value | Language |
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dc.contributor.author | Saavedra, Ana | - |
dc.contributor.author | Puigdellívol Cañadell, Maria del Mar | - |
dc.contributor.author | Tyebji, Shiraz | - |
dc.contributor.author | Kurup, Pradeep | - |
dc.contributor.author | Xu, Jian | - |
dc.contributor.author | Ginés Padrós, Silvia | - |
dc.contributor.author | Alberch i Vié, Jordi, 1959- | - |
dc.contributor.author | Lombroso, Paul J. | - |
dc.contributor.author | Pérez Navarro, Esther | - |
dc.date.accessioned | 2022-03-25T18:55:15Z | - |
dc.date.available | 2022-03-25T18:55:15Z | - |
dc.date.issued | 2016-08 | - |
dc.identifier.issn | 0893-7648 | - |
dc.identifier.uri | http://hdl.handle.net/2445/184407 | - |
dc.description.abstract | Brain-derived neurotrophic factor (BDNF) promotes synaptic strengthening through the regulation of kinase and phosphatase activity. Conversely, striatal-enriched protein tyrosine phosphatase (STEP) opposes synaptic strengthening through inactivation or internalization of signaling molecules. Here, we investigated whether BDNF regulates STEP levels/activity. BDNF induced a reduction of STEP61 levels in primary cortical neurons, an effect that was prevented by inhibition of tyrosine kinases, phospholipase C gamma, or the ubiquitin-proteasome system (UPS). The levels of pGluN2B(Tyr1472) and pERK1/2(Thr202/Tyr204), two STEP substrates, increased in BDNF-treated cultures, and blockade of the UPS prevented STEP61 degradation and reduced BDNF-induced GluN2B and ERK1/2 phosphorylation. Moreover, brief or sustained cell depolarization reduced STEP61 levels in cortical neurons by different mechanisms. BDNF also promoted UPS-mediated STEP61 degradation in cultured striatal and hippocampal neurons. In contrast, nerve growth factor and neurotrophin-3 had no effect on STEP61 levels. Our results thus indicate that STEP61 degradation is an important event in BDNF-mediated effects. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Humana Press. | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1007/s12035-015-9335-7 | - |
dc.relation.ispartof | Molecular Neurobiology, 2016, vol. 53, num. 6, p. 4261-4273 | - |
dc.relation.uri | https://doi.org/10.1007/s12035-015-9335-7 | - |
dc.rights | (c) Humana Press., 2016 | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Neurones | - |
dc.subject.classification | Proteïnes | - |
dc.subject.classification | Proteïna-tirosina-fosfatasa | - |
dc.subject.classification | Sinapsi | - |
dc.subject.other | Neurons | - |
dc.subject.other | Proteins | - |
dc.subject.other | Protein-tyrosine phosphatase | - |
dc.subject.other | Synapses | - |
dc.title | BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 654620 | - |
dc.date.updated | 2022-03-25T18:55:16Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26223799 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
Files in This Item:
File | Description | Size | Format | |
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654620.pdf | 1.44 MB | Adobe PDF | View/Open |
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