Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/184407
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dc.contributor.authorSaavedra, Ana-
dc.contributor.authorPuigdellívol Cañadell, Maria del Mar-
dc.contributor.authorTyebji, Shiraz-
dc.contributor.authorKurup, Pradeep-
dc.contributor.authorXu, Jian-
dc.contributor.authorGinés Padrós, Silvia-
dc.contributor.authorAlberch i Vié, Jordi, 1959--
dc.contributor.authorLombroso, Paul J.-
dc.contributor.authorPérez Navarro, Esther-
dc.date.accessioned2022-03-25T18:55:15Z-
dc.date.available2022-03-25T18:55:15Z-
dc.date.issued2016-08-
dc.identifier.issn0893-7648-
dc.identifier.urihttp://hdl.handle.net/2445/184407-
dc.description.abstractBrain-derived neurotrophic factor (BDNF) promotes synaptic strengthening through the regulation of kinase and phosphatase activity. Conversely, striatal-enriched protein tyrosine phosphatase (STEP) opposes synaptic strengthening through inactivation or internalization of signaling molecules. Here, we investigated whether BDNF regulates STEP levels/activity. BDNF induced a reduction of STEP61 levels in primary cortical neurons, an effect that was prevented by inhibition of tyrosine kinases, phospholipase C gamma, or the ubiquitin-proteasome system (UPS). The levels of pGluN2B(Tyr1472) and pERK1/2(Thr202/Tyr204), two STEP substrates, increased in BDNF-treated cultures, and blockade of the UPS prevented STEP61 degradation and reduced BDNF-induced GluN2B and ERK1/2 phosphorylation. Moreover, brief or sustained cell depolarization reduced STEP61 levels in cortical neurons by different mechanisms. BDNF also promoted UPS-mediated STEP61 degradation in cultured striatal and hippocampal neurons. In contrast, nerve growth factor and neurotrophin-3 had no effect on STEP61 levels. Our results thus indicate that STEP61 degradation is an important event in BDNF-mediated effects.-
dc.format.extent13 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherHumana Press.-
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1007/s12035-015-9335-7-
dc.relation.ispartofMolecular Neurobiology, 2016, vol. 53, num. 6, p. 4261-4273-
dc.relation.urihttps://doi.org/10.1007/s12035-015-9335-7-
dc.rights(c) Humana Press., 2016-
dc.sourceArticles publicats en revistes (Biomedicina)-
dc.subject.classificationNeurones-
dc.subject.classificationProteïnes-
dc.subject.classificationProteïna-tirosina-fosfatasa-
dc.subject.classificationSinapsi-
dc.subject.otherNeurons-
dc.subject.otherProteins-
dc.subject.otherProtein-tyrosine phosphatase-
dc.subject.otherSynapses-
dc.titleBDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec654620-
dc.date.updated2022-03-25T18:55:16Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid26223799-
Appears in Collections:Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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