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DC Field | Value | Language |
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dc.contributor.author | González Díaz, Aida | - |
dc.contributor.author | Carrera Salinas, Anna | - |
dc.contributor.author | Pinto, Miguel | - |
dc.contributor.author | Cubero, Meritxell | - |
dc.contributor.author | Ende, Arie van der | - |
dc.contributor.author | Langereis, Jeroen D. | - |
dc.contributor.author | Domínguez, M. Ángeles | - |
dc.contributor.author | Ardanuy, Carmen | - |
dc.contributor.author | Bajanca Lavado, Paula | - |
dc.contributor.author | Marti, Sara | - |
dc.date.accessioned | 2022-03-28T13:25:03Z | - |
dc.date.available | 2022-03-28T13:25:03Z | - |
dc.date.issued | 2022-02-24 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/184448 | - |
dc.description.abstract | Haemophilus influenzae is an opportunistic pathogen adapted to the human respiratory tract. Non-typeable H. influenzae are highly heterogeneous, but few studies have analysed the genomic variability of capsulated strains. This study aims to examine the genetic diversity of 37 serotype f isolates from the Netherlands, Portugal, and Spain, and to compare all capsulated genomes available on public databases. Serotype f isolates belonged to CC124 and shared few single nucleotide polymorphisms (SNPs) (n = 10,999), but a high core genome (> 80%). Three main clades were identified by the presence of 75, 60 and 41 exclusive genes for each clade, respectively. Multi-locus sequence type analysis of all capsulated genomes revealed a reduced number of clonal complexes associated with each serotype. Pangenome analysis showed a large pool of genes (n = 6360), many of which were accessory genome (n = 5323). Phylogenetic analysis revealed that serotypes a, b, and f had greater diversity. The total number of SNPs in serotype f was significantly lower than in serotypes a, b, and e (p < 0.0001), indicating low variability within the serotype f clonal complexes. Capsulated H. influenzae are genetically homogeneous, with few lineages in each serotype. Serotype f has high genetic stability regardless of time and country of isolation. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Science and Business Media LLC | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-022-07185-5 | - |
dc.relation.ispartof | Scientific Reports, 2022, vol 12, num 1 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-022-07185-5 | - |
dc.rights | cc by (c) Gonzalez Diaz, Aida et al, 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Bacils | - |
dc.subject.classification | Genòmica | - |
dc.subject.other | Bacillus (Bacteria) | - |
dc.subject.other | Genomics | - |
dc.title | Comparative pangenome analysis of capsulated Haemophilus influenzae serotype f highlights their high genomic stability | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-03-25T09:54:56Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 35210526 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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s41598-022-07185-5.pdf | 3.49 MB | Adobe PDF | View/Open |
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