Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/184465
Title: | A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood. |
Author: | Gassó Astorga, Patricia Rodríguez Ferret, Natalia Martinez Pinteño, Albert Mezquida Mateos, Gisela Ribeiro, M. González Peñas, Javier Zorrilla, Iñaki Martínez Sadurní, L. Rodriguez Jimenez, Roberto Corripio, Iluminada Sarró, Salvador Ibáñez, A. Usall i Rodié, Judith Lobo, A. Morén Núñez, Constanza Cuesta, Manuel J. Parellada, Mara González-Pinto, Ana Berrocoso, Esther Bernardo Arroyo, Miquel Mas Herrero, Sergi 2EPs Group |
Keywords: | Esquizofrènia Psiquiatria Schizophrenia Psychiatry |
Issue Date: | 19-Oct-2021 |
Publisher: | Nature Publishing Group |
Abstract: | Little is known about the pathophysiological mechanisms of relapse in first-episode schizophrenia, which limits the study of potential biomarkers. To explore relapse mechanisms and identify potential biomarkers for relapse prediction, we analyzed gene expression in peripheral blood in a cohort of first-episode schizophrenia patients with less than 5 years of evolution who had been evaluated over a 3-year follow-up period. A total of 91 participants of the 2EPs project formed the sample for baseline gene expression analysis. Of these, 67 provided biological samples at follow-up (36 after 3 years and 31 at relapse). Gene expression was assessed using the Clariom S Human Array. Weighted gene co-expression network analysis was applied to identify modules of co-expressed genes and to analyze their preservation after 3 years of follow-up or at relapse. Among the 25 modules identified, one module was semi-conserved at relapse (DarkTurquoise) and was enriched with risk genes for schizophrenia, showing a dysregulation of the TCF4 gene network in the module. Two modules were semi-conserved both at relapse and after 3 years of follow-up (DarkRed and DarkGrey) and were found to be biologically associated with protein modification and protein location processes. Higher expression of DarkRed genes was associated with higher risk of suffering a relapse and early appearance of relapse (p = 0.045). Our findings suggest that a dysregulation of the TCF4 network could be an important step in the biological process that leads to relapse and suggest that genes related to the ubiquitin proteosome system could be potential biomarkers of relapse. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41398-021-01645-8 |
It is part of: | Translational Psychiatry, 2021, vol. 11, num. 1, p. 539 |
URI: | https://hdl.handle.net/2445/184465 |
Related resource: | https://doi.org/10.1038/s41398-021-01645-8 |
ISSN: | 2158-3188 |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
721309.pdf | 1.9 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License