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http://hdl.handle.net/2445/184472
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DC Field | Value | Language |
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dc.contributor.author | Meira, Fernanda | - |
dc.contributor.author | Moreno García, Estela | - |
dc.contributor.author | Linares, Laura | - |
dc.contributor.author | Macaya, Irene | - |
dc.contributor.author | Tomé, Adrià | - |
dc.contributor.author | Hernández-Meneses, Marta | - |
dc.contributor.author | Albiach, Laia | - |
dc.contributor.author | Morata, Laura | - |
dc.contributor.author | Letona Giménez, Laura | - |
dc.contributor.author | Bodro, Marta | - |
dc.contributor.author | Cózar Llistó, Alberto | - |
dc.contributor.author | Cardozo Espinola, Celia | - |
dc.contributor.author | Chumbita, Mariana | - |
dc.contributor.author | Pitart, Cristina | - |
dc.contributor.author | Ambrosioni, Juan | - |
dc.contributor.author | Rico, Verónica | - |
dc.contributor.author | Agüero, Daiana | - |
dc.contributor.author | Puerta Alcalde, Pedro | - |
dc.contributor.author | Garcia-Pouton, Nicole | - |
dc.contributor.author | Marco, Francesc | - |
dc.contributor.author | Garcia Vidal, Carolina | - |
dc.contributor.author | Soriano Viladomiu, Alex | - |
dc.contributor.author | Martínez, José Antonio | - |
dc.date.accessioned | 2022-03-28T14:13:40Z | - |
dc.date.available | 2022-03-28T14:13:40Z | - |
dc.date.issued | 2021-06-11 | - |
dc.identifier.issn | 2193-8229 | - |
dc.identifier.uri | http://hdl.handle.net/2445/184472 | - |
dc.description.abstract | The study aim was to assess the influence of inflammatory response modifiers, including anti-interleukin-6 (IL-6) biologics and corticosteroids, on the incidence of hospital-acquired infections in patients with coronavirus disease 2019 (COVID-19). METHODS: Case-control study performed at a university hospital from February 26 to May 26, 2020. Cases were defined as patients with COVID-19 who developed hospital-acquired infections. For each case, two controls were selected among patients without infections. Cases and controls were matched obeying three criteria in a hierarchical sequence: length of hospital stay up until the first infection; comorbidity; and need for Intensive care unit (ICU) admission. Conditional logistic regression analysis was used to estimate the association of exposures with being a case. RESULTS: A total of 71 cases and 142 controls were included. Independent predictors for acquiring a hospital infection were chronic liver disease [odds ratio (OR) 16.56, 95% CI 1.87-146.5, p = 0.012], morbid obesity (OR 6.11, 95% CI 1.06-35.4, p = 0.043), current or past smoking (OR 4.15, 95% CI 1.45-11.88, p = 0.008), exposure to hydroxychloroquine (OR 0.2, 95% CI 0.041-1, p = 0.053), and invasive mechanical ventilation (OR 61.5, 95% CI 11.08-341, p ≤ 0.0001). CONCLUSIONS: Inflammatory response modifiers had no influence on acquisition of nosocomial infections in admitted patients with COVID-19. Hospital-acquired infections primarily occurred in the critically ill and invasive mechanical ventilation was the main exposure conferring risk. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1007/s40121-021-00477-9 | - |
dc.relation.ispartof | Infectious Diseases and Therapy, 2021, vol. 10, num. 3, p. 1407-1418 | - |
dc.relation.uri | https://doi.org/10.1007/s40121-021-00477-9 | - |
dc.rights | cc-by-nc (c) Meira, Fernanda et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | COVID-19 | - |
dc.subject.classification | SARS-CoV-2 | - |
dc.subject.classification | Infeccions nosocomials | - |
dc.subject.other | COVID-19 | - |
dc.subject.other | SARS-CoV-2 | - |
dc.subject.other | Nosocomial infections | - |
dc.title | Impact of Inflammatory Response Modifiers on the Incidence of Hospital-Acquired Infections in Patients with COVID-19. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 722369 | - |
dc.date.updated | 2022-03-28T14:13:40Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) |
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722369.pdf | 320.88 kB | Adobe PDF | View/Open |
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