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http://hdl.handle.net/2445/184494
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DC Field | Value | Language |
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dc.contributor.author | Just Baringo, Xavier | - |
dc.contributor.author | Yeste Vázquez, Alejandro | - |
dc.contributor.author | Moreno Morales, Javier | - |
dc.contributor.author | Ballesté Delpierre, Clara Celia | - |
dc.contributor.author | Vila Estapé, Jordi | - |
dc.contributor.author | Giralt Lledó, Ernest | - |
dc.date.accessioned | 2022-03-29T09:24:02Z | - |
dc.date.available | 2022-03-29T09:24:02Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 0947-6539 | - |
dc.identifier.uri | http://hdl.handle.net/2445/184494 | - |
dc.description.abstract | The introduction of a novel tetra-ortho-chloroazobenzene amino acid (CEBA) has enabled photoswitching of the antimicrobial activity of tyrocidine A analogues by using exclusively visible light, granting spatiotemporal control under benign conditions. Compounds bearing this photo- switchable amino acid become active upon irradiation with red light, but quickly turn-off upon exposure to other visible light wavelengths. Critically, sunlight quickly triggers isomerisation of the red light-activated compounds into their original trans form, offering an ideal platform for self-deactivation upon release into the environment. Linear analogues of tyrocidine A were found to provide the best photocontrol of their antimicrobial activity, leading to compounds active against Acinetobacter baumannii upon isomerisation. Exploration of their N- and C-termini has provided insights into key elements of their structure and has allowed obtaining new antimicrobials displaying excellent strain selectivity and photocontrol. | - |
dc.format.extent | 5 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-VCH | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1002/chem.202102370 | - |
dc.relation.ispartof | Chemistry-A European Journal, 2021, vol. 27, p. 12987-12991 | - |
dc.relation.uri | https://doi.org/10.1002/chem.202102370 | - |
dc.rights | cc by-nc-nd (c) Just Baringo et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | Espectroscòpia molecular | - |
dc.subject.classification | Aminoàcids | - |
dc.subject.other | Molecular spectroscopy | - |
dc.subject.other | Amino acids | - |
dc.title | Controlling Antibacterial Activity Exclusively with Visible Light: Introducing a Tetra-ortho-Chloro-Azobenzene Amino Acid | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 714521 | - |
dc.date.updated | 2022-03-29T09:24:02Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
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714521.pdf | 4.76 MB | Adobe PDF | View/Open |
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