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Title: | Walnuts, Long-Chain Polyunsaturated Fatty Acids, and Adolescent Brain Development: Protocol for the Walnuts Smart Snack Dietary Intervention Trial |
Author: | Julvez, Jordi Gignac, Florence Fernández Barrés, Silvia Romaguera, Dora Sala Vila, Aleix Ranzani, Otavio T Persavento, Cecilia Delgado, Anna Carol, Albert Torrent, Jaume Gonzalez, Judith Roso, Eduard Barrera Gómez, José López Vicente, Mònica García Esteban, Raquel Boucher, Olivier Forns, Joan Burgaleta Díaz, Miguel, 1981- Sebastián Gallés, Núria Canals, Josefina Arija Val, Victoria Basagaña, Xavier Ros Rahola, Emilio Vendrell, Joan Salas Salvadó, Jordi Sunyer Deu, Jordi |
Keywords: | Neuropsicologia Dieta Cuina (Nous) Adolescents Cervell Àcids grassos insaturats Àcids grassos omega-3 Assaigs clínics Neuropsychology Diet Cooking (Nuts) Teenagers Brain Unsaturated fatty acids Omega-3 fatty acids Clinical trials |
Issue Date: | 8-Jun-2021 |
Publisher: | Frontiers Media |
Abstract: | Background: Adolescence, when the most complex behaviors are refined to adult sophistication, represents a major window of opportunity and vulnerability for neuropsychological development. To support and protect this complex and active brain growth, different nutritional components considered essential need to be acquired from the diet. For instance, omega-3 fatty acids are mainly obtained from seafood, seeds, and walnuts. Known for their rich lipid profile, walnuts contain sizable amounts of an essential fatty acid, alpha-linolenic acid (ALA), the vegetable omega-3 fatty acid that is the precursor of two longer-chain omega-3 polyunsaturated fatty acids (omega-3 PUFA): docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids. While there is growing evidence of neuropsychological improvements in the young developing brain associated with omega-3 PUFA intake, few studies have examined whether consuming walnuts during adolescence entails similar beneficial effects. There is a need to further explore the ways in which walnuts influence youthful brain function, particularly for the long-term. Thus, we designed the WALNUTs study (WSS), a population-based randomized controlled trial conducted in adolescents in Barcelona, Spain. We hypothesize that walnut intake will increase omega-3 PUFA tissue availability (particularly ALA) to a level that enhances the neuropsychological development during adolescence. Methodology/Design: We conducted a 6-month population-based randomized controlled trial in teenagers (n = 800) and we aimed to determine the effectiveness of the intervention (four walnuts per day, or 30 kernel g, ~1.5g of ALA) in enhancing brain neuropsychological and socio-emotional development compared to a control group with no walnut intervention. Before randomization, different neuropsychological tests were recorded for all participants, and blood samples (in a subsample of participants) were collected to measure omega-3 PUFA levels at baseline, and all again, after randomization and the intervention. The data is now collected and we will conduct linear regression models to assess the effect of the intervention. Discussion: The WALNUTs (WSS) study results will allow us to better understand the role of plant-based omega-3 PUFA intake from regular walnut consumption on neuropsychological development during adolescence. Results could be translated into nutritional public health recommendations targeting teenagers. Trial Registration: ClinicalTrials.gov, U.S. National Library of Medicine, National Institutes of Health # NCT02590848. Retrospectively registered 29/10/2015. |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fped.2021.593847 |
It is part of: | Frontiers in Pediatrics, 2021, vol. 9, p. 593847 |
URI: | http://hdl.handle.net/2445/184502 |
Related resource: | https://doi.org/10.3389/fped.2021.593847 |
ISSN: | 2296-2360 |
Appears in Collections: | Articles publicats en revistes (Psicologia Clínica i Psicobiologia) |
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