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Title: | Diabetes, sarcopenia and chronic kidney disease; the screening for CKD among older people across Europe (SCOPE) study |
Author: | Formiga Pérez, Francesc Moreno‑ González, Rafael Corsonello, Andrea Carlsson, Axel C. Ärnlöv, Johan Mattace-Raso, Francesco Kostka, Tomasz Weingart, Christian Roller-Wirnsberger, Regina Tap, Lisanne Guligowska, Agnieszka Sieber, Cornel Wirnsberger, Gerhard Artzi-Medvedik, Rada Yehoshua, Ilan Giuli, Cinzia Lattanzio, Fabrizia Corbella, Xavier |
Keywords: | Diabetis Malalties del fetge Malalties cròniques Insuficiència renal Persones grans Diabetes Liver diseases Chronic diseases Renal insufficiency Older people |
Issue Date: | 29-Mar-2022 |
Publisher: | BioMed Central |
Abstract: | ackground:Sarcopenia may be more present in older adults with diabetes (DM). Accordingly, we evaluated the prevalence of sarcopenia and its associated risk factors among community‑dwelling older adults with DM.Methods:A cross‑sectional analysis of older people living in the community was carried out. Participants (aged 75 years and more) came from an European multicenter prospective cohort (SCOPE study). Global geriatric assess‑ment including short physical performance battery, handgrip strength test and bioelectrical impedance analysis was performed. Sarcopenia was defined by the updated criteria of the European Working Group on Sarcopenia in Older People (EWGSOP2). Estimated glomerular filtration rate (eGFR) was calculated using Berlin Initiative Study (BIS) to define the stages of chronic kidney disease (CKD). Previous known DM was defined as physician‑diagnosed DM reg‑istered in the patient's medical record or the use of DM‑related medications. Hemoglobin A1c levels and specific DM therapies administered were collected. Time elapsed from the first diagnosis of DM was not collected and, therefore, was not included in the analyses.Results:A total of 1,420 subjects were evaluated with a median age of 79.0 (6.0) years, of which 804 (56.6%) were women and 615 (43.3%) men; 315 (22.2%) participants had prior DM diagnosis, with a median age of 80.0 (6.0), 146 (46.3%) were women. Using EWGSOP2 definition, 150 (10.6%) participants in the SCOPE study met diagnostic criteria for sarcopenia. Participants without diabetes had more often normal results in the 3 sarcopenia components than participants with diabetes [887 (80.31%) vs. 227 (72.1%), p=0.002], highlighting higher percentages of severe sarco‑penia in participants with diabetes [27 (8.6%) vs. 58 (5.2%), p=0.028]. Confirmed or severe sarcopenia was detected in 41 (13%) participants with diabetes and 109 (9.8%) participants without diabetes (p=0.108). According to BIS equa‑tion, sarcopenia was not significantly more prevalent in the more advanced stages of CKD (p=0.845). In multivariate analyses, older age (odds ratios [OR], 1.17; 95% confidence interval [CI], 1.08-1.27), and lower body mass index (OR, 0.79; 95% CI, 0.71-0.89 were associated with the presence of sarcopenia.Conclusions:One tenth of all older community‑dwelling subjects have sarcopenia. Older age and being thinner, but not worse renal function, were associated with higher prevalence of sarcopenia in older older adults with diabetes. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/jcm11071876 |
It is part of: | BMC Geriatrics, vol. 22, 254, 2022 |
URI: | http://hdl.handle.net/2445/184559 |
Related resource: | https://doi.org/10.3390/jcm11071876 |
ISSN: | 1471-2318 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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