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Title: Rush hour of LATs towards their transport cycle
Author: Nicolàs-Aragó, Adrià
Fort i Baixeras, Joana
Palacín Prieto, Manuel
Errasti-Murugarren, Ekaitz
Keywords: Aminoàcids
Proteïnes portadores
Malalties rares
Amino acids
Carrier proteins
Rare diseases
Issue Date: 1-Aug-2021
Publisher: MDPI
Abstract: The mammalian SLC7 family comprises the L-amino acid transporters (LATs) and the cationic amino acid transporters (CATs). The relevance of these transporters is highlighted by their involvement in several human pathologies, including inherited rare diseases and acquired diseases, such as cancer. In the last four years, several crystal or cryo-EM structures of LATs and CATs have been solved. These structures have started to fill our knowledge gap that previously was based on the structural biology of remote homologs of the amino acid-polyamine-organocation (APC) transporters. This review recovers this structural and functional information to start generating the molecular bases of the transport cycle of LATs. Special attention is given to the known transporter conformations within the transport cycle and the molecular bases for substrate interaction and translocation, including the asymmetric interaction of substrates at both sides of the plasma membrane. Keywords: APC; LATs; SLC7; transport cycle; structure; substrate binding; substrate translocation
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It is part of: Membranes, 2021, vol. 11, num. 8, p. 1-13
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ISSN: 2077-0375
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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