Por favor, use este identificador para citar o enlazar este documento: https://hdl.handle.net/2445/184625
Título: Early Access to Medicines: Use of Multicriteria Decision Analysis (MCDA) as a Decision Tool in Catalonia (Spain)
Autor: Gasol, Montse
Paco, Noelia
Guarga, Laura
Bosch Gil, Josep Àngel
Pontes García, Caridad
Obach Cortadellas, Mercè
Materia: Accés als medicaments
Malalties rares
Drug accessibility
Rare diseases
Fecha de publicación: 1-mar-2022
Publicado por: MDPI AG
Resumen: Early access to medicines allows the prescription of a medicine before it is available in the public formulary to patients with severe or rare diseases with high unmet needs who have no authorised therapeutic alternatives available. In this context, consistent decision making is difficult, and a systematic assessment procedure could be useful to tackle complex situations and guarantee the equity of medicines' access. A multidisciplinary panel (MP) conducted four workshops to develop an early access framework based on a reflective multiple criteria decision analysis (MCDA). A set of 12 criteria was agreed: eight quantitative (severity of disease, urgency, efficacy, safety, internal and external validity, therapeutic benefit and plausibility) and four qualitative (therapeutic alternative, existence of precedents, management impact and costs). Quantitative criteria were weighted using a five-point scale. The relative importance of quantitative criteria had mean weights from 4.7 to 3.6, showing its relevance in the decisions. The framework was tested using two case studies, and reliability was assessed by re-test. The re-test revealed no statistical differences, indicating the consistency and replicability of the framework developed. MCDA may help to structure discussions for heterogeneous treatment requests, providing predictability and robustness in decision making involving sensitive and complex situations.
Nota: Reproducció del document publicat a: https://doi.org/10.3390/jcm11051353
Es parte de: Journal of Clinical Medicine, 2022, vol 11, num 5
URI: https://hdl.handle.net/2445/184625
Recurso relacionado: https://doi.org/10.3390/jcm11051353
ISSN: 2077-0383
Aparece en las colecciones:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Archivos de este documento:
Archivo Descripción DimensionesFormato 
jcm-11-01353.pdf1.07 MBAdobe PDFMostrar/Abrir


Este documento está sujeto a una Licencia Creative Commons Creative Commons