Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/184708
Title: | Lactate in the tumor microenvironment: an essential molecule in cancer progression and treatment |
Author: | Pérez Tomás, Ricardo E. Pérez Guillén, Isabel |
Keywords: | Enzims Acidosi Càncer Enzymes Acidosis Cancer |
Issue Date: | 3-Oct-2020 |
Publisher: | MDPI |
Abstract: | Cancer is a complex disease that includes the reprogramming of metabolic pathways by malignant proliferating cells, including those affecting the tumor microenvironment (TME). The 'TME concept' was introduced in recognition of the roles played by factors other than tumor cells in cancer progression. In response to the hypoxic or semi-hypoxic characteristic of the TME, cancer cells generate a large amount of lactate via the metabolism of glucose and glutamine. Export of this newly generated lactate by the tumor cells together with H+ prevents intracellular acidification but acidifies the TME. In recent years, the importance of lactate and acidosis in carcinogenesis has gained increasing attention, including the role of lactate as a tumor-promoting metabolite. Here we review the existing literature on lactate metabolism in tumor cells and the ability of extracellular lactate to direct the metabolic reprogramming of those cells. Studies demonstrating the roles of lactate in biological processes that drive or sustain carcinogenesis (tumor promotion, angiogenesis, metastasis and tumor resistance) and lactate's role as an immunosuppressor that contributes to tumor evasion are also considered. Finally, we consider recent therapeutic efforts using available drugs directed at and interfering with lactate production and transport in cancer treatment. |
Note: | Reproducció del document publicat a: http://10.3390/cancers12113244 |
It is part of: | Cancers, 2020, vol. 12, num. 11, p. 3244 |
URI: | https://hdl.handle.net/2445/184708 |
ISSN: | 2072-6694 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
707008.pdf | 2.74 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License