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DC Field | Value | Language |
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dc.contributor.author | Ortiz-Prado, Esteban | - |
dc.contributor.author | Espinosa, Patricio S. | - |
dc.contributor.author | Borrero, Alfredo | - |
dc.contributor.author | Cordovez, Simone Pierina | - |
dc.contributor.author | Vásconez González, Jorge Eduardo | - |
dc.contributor.author | Barreto-Grimales, Alejandra | - |
dc.contributor.author | Coral-Almeida, Marco | - |
dc.contributor.author | Henríquez-Trujillo, Aquiles R. | - |
dc.contributor.author | Simbaña-Rivera, Katherine | - |
dc.contributor.author | Gomez-Barreno, Lenin | - |
dc.contributor.author | Viscor Carrasco, Ginés | - |
dc.contributor.author | Roderick, Paul | - |
dc.date.accessioned | 2022-04-06T13:32:36Z | - |
dc.date.available | 2022-04-06T13:32:36Z | - |
dc.date.issued | 2021-09-30 | - |
dc.identifier.issn | 1664-042X | - |
dc.identifier.uri | http://hdl.handle.net/2445/184771 | - |
dc.description.abstract | Worldwide, more than 5.7% of the population reside above 1,500m of elevation. It has been hypothesized that acute short-term hypoxia exposure could increase the risk of developing a stroke. Studies assessing the effect of altitude on stroke have provided conflicting results, some analyses suggest that long-term chronic exposure could be associated with reduced mortality and lower stroke incidence rates. An ecological analysis of all stroke hospital admissions, mortality rates and disability-adjusted life years in Ecuador was performed from 2001-2017. The cases and population at risk were categorized in low (<1,500m), moderate (1,500m -2,500m), high (2,500m -3,500m) and very high altitude (3,500-5,500m) according to the place of residence. The derived crude and direct standardized age-sex adjusted mortality and hospital admission rates were calculated. A total of 38,201 deaths and 75,893 stroke-related hospital admissions were reported. High altitude populations (HAP) had lower stroke mortality in men (OR: 0.91 [0.88 - 0.95]) and women (OR: 0.83 [0.79 - 0.86]). In addition, HAP had a significant lower risk of getting admitted to the hospital when compared with the low altitude group in men (OR: 0.55 [CI95% 0.54 - 0.56]) and women (OR: 0.65 [CI95% [0.64 - 0.66]). This is the first epidemiological study that aims to elucidate the association between stroke and altitude using four different elevation ranges. Our findings suggest that living at higher elevations offers a reduction or the risk of dying due to stroke as well as a reduction in the probability of being admitted to the hospital. Nevertheless, this protective factor has a stronger effect between 2,000m to 3,500 m. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fphys.2021.733928 | - |
dc.relation.ispartof | Frontiers in Physiology, 2021, vol. 12, num. e733928, p. 1-14 | - |
dc.relation.uri | https://doi.org/10.3389/fphys.2021.733928 | - |
dc.rights | cc-by (c) Ortiz-Prado, Esteban et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) | - |
dc.subject.classification | Mortalitat | - |
dc.subject.classification | Angiogènesi | - |
dc.subject.classification | Influència de l'altitud | - |
dc.subject.classification | Equador | - |
dc.subject.other | Mortality | - |
dc.subject.other | Neovascularization | - |
dc.subject.other | Influence of altitude | - |
dc.subject.other | Ecuador | - |
dc.title | Stroke related mortality at different altitudes: A 17-year nationwide population-based analysis from Ecuador | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 714033 | - |
dc.date.updated | 2022-04-06T13:32:36Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) |
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714033.pdf | 2.21 MB | Adobe PDF | View/Open |
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