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Title: Leveraging omics to understand the molecular basis of acute-on-chronic liver failure.
Author: Clària i Enrich, Joan
Keywords: Cirrosi hepàtica
Resposta immunitària
Hepatic cirrhosis
Immune response
Issue Date: 11-Aug-2021
Publisher: De Gruyter
Abstract: Acute-on-chronic liver failure (ACLF) is a complex syndrome that develops in patients with acutely decompensated cirrhosis. In this condition, dysbalanced immune function and excessive systemic inflammation are closely associated with organ failure and high short-term mortality. In this review, we describe how omic technologies have contributed to the characterization of the hyperinflammatory state in patients with acutely decompensated cirrhosis developing ACLF, with special emphasis on the role of metabolomics, lipidomics and transcriptomics in profiling the triggers (pathogen- and damage-associated molecular patterns [PAMPs and DAMPs]) and effector molecules (cytokines, chemokines, growth factors and bioactive lipid mediators) that lead to activation of the innate immune system. This review also describes how omic approaches can be invaluable tools to accelerate the identification of novel biomarkers that could guide the implementation of novel therapies/interventions aimed at protecting these patients from excessive systemic inflammation and organ failure.
Note: Reproducció del document publicat a:
It is part of: Advances in Laboratory Medicine/Avances en Medicina de Laboratorio, 2021, vol. 2, num. 4, p. 516-527
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ISSN: 2628-491X
Appears in Collections:Articles publicats en revistes (Biomedicina)

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