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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/184906
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dc.contributor.authorLucero Borja, Diego Sebastián-
dc.contributor.authorCastilla, Òscar-
dc.contributor.authorBarbas Cañero, Rafael-
dc.contributor.authorSubirats i Vila, Xavier-
dc.contributor.authorRàfols Llach, Clara-
dc.date.accessioned2022-04-13T15:56:12Z-
dc.date.available2022-04-13T15:56:12Z-
dc.date.issued2017-12-24-
dc.identifier.issn1848-7718-
dc.identifier.urihttps://hdl.handle.net/2445/184906-
dc.description.abstractIn the present study the solubility-pH profiles of sibutramine free base and its hydrochloride salt were determined in the pH range between 2.0 and 9.5 by means of the recommended shake-flask method, and the solids collected were dried and studied by X-ray diffraction in order to elucidate their free base or salt structure. Above pHmax (or Gibbs pKa) the solid collected was always identified as free base, whatever the sibutramine species (free base or hydrochloride salt) initially solved. However, in the pH range below pHmax different solids were isolated depending on the buffers employed.-
dc.format.extent4 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherIAPC Publishing-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.5599/admet.5.4.452-
dc.relation.ispartofADMET & DMPK, 2017, vol. 5, num. 4, p. 253-256-
dc.relation.urihttps://doi.org/10.5599/admet.5.4.452-
dc.rightscc-by (c) Lucero Borja, Diego Sebastián et al., 2017-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.sourceArticles publicats en revistes (Enginyeria Química i Química Analítica)-
dc.subject.classificationSolubilitat-
dc.subject.classificationSals-
dc.subject.classificationPotenciometria-
dc.subject.otherSolubility-
dc.subject.otherSalts-
dc.subject.otherPotentiometry-
dc.titleSolubility-pH profiles of a free base and its salt: sibutramine as a case study-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec675091-
dc.date.updated2022-04-13T15:56:12Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Enginyeria Química i Química Analítica)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

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