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http://hdl.handle.net/2445/184911
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DC Field | Value | Language |
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dc.contributor.author | Bäuerl, Christine | - |
dc.contributor.author | Randazzo, Walter | - |
dc.contributor.author | Sánchez, Gloria | - |
dc.contributor.author | Selma-Royo, Marta | - |
dc.contributor.author | Garcia-Verdevio, Elia | - |
dc.contributor.author | Martínez Rodríguez, Laura | - |
dc.contributor.author | Parra-Llorca, Anna | - |
dc.contributor.author | Lerin, Carles | - |
dc.contributor.author | Fumadó, Victoria | - |
dc.contributor.author | Crovetto, Francesca | - |
dc.contributor.author | Crispi Brillas, Fàtima | - |
dc.contributor.author | Pérez-Cano, Francisco J. | - |
dc.contributor.author | Rodríguez, Gerardo | - |
dc.contributor.author | Ruíz-Redondo, Gema | - |
dc.contributor.author | Campoy, Cristina | - |
dc.contributor.author | Martínez Costa, Cecilia | - |
dc.contributor.author | Collado, Maria Carmen | - |
dc.contributor.author | MilkCORONA study team | - |
dc.date.accessioned | 2022-04-14T06:20:37Z | - |
dc.date.available | 2022-04-14T06:20:37Z | - |
dc.date.issued | 2021-08-20 | - |
dc.identifier.issn | 1359-2998 | - |
dc.identifier.uri | http://hdl.handle.net/2445/184911 | - |
dc.description.abstract | Objectives To develop and validate a specific protocol for SARS-CoV-2 detection in breast milk matrix and to determine the impact of maternal SARS-CoV-2 infection on the presence, concentration and persistence of specific SARS-CoV-2 antibodies. Design and patients This is a prospective, multicentre longitudinal study (April-December 2020) in 60 mothers with SARS-CoV-2 infection and/or who have recovered from COVID-19. A control group of 13 women before the pandemic were also included. Setting Seven health centres from different provinces in Spain. Main outcome measures Presence of SARS-CoV-2 RNA in breast milk, targeting the N1 region of the nucleocapsid gene and the envelope (E) gene; presence and levels of SARS-CoV-2-specific immunoglobulins (Igs)¿IgA, IgG and IgM¿in breast milk samples from patients with COVID-19. Results All breast milk samples showed negative results for presence of SARS-CoV-2 RNA. We observed high intraindividual and interindividual variability in the antibody response to the receptor-binding domain of the SARS-CoV-2 spike protein for each of the three isotypes IgA, IgM and IgG. Main Protease (MPro) domain antibodies were also detected in milk. 82.9% (58 of 70) of milk samples were positive for at least one of the three antibody isotypes, with 52.9% of these positive for all three Igs. Positivity rate for IgA was relatively stable over time (65.2%-87.5%), whereas it raised continuously for IgG (from 47.8% for the first 10 days to 87.5% from day 41 up to day 206 post-PCR confirmation). Conclusions Our study confirms the safety of breast feeding and highlights the relevance of virus-specific SARS-CoV-2 antibody transfer. This study provides crucial data to support official breastfeeding recommendations based on scientific evidence. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BMJ Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1136/archdischild-2021-322463 | - |
dc.relation.ispartof | Archives of Disease in Childhood: Fetal & Neonatal, 2021, vol. 107, num. 2, p. 216-221 | - |
dc.relation.uri | https://doi.org/10.1136/archdischild-2021-322463 | - |
dc.rights | cc-by-nc (c) Bäuerl, Christine et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.source | Articles publicats en revistes (Bioquímica i Fisiologia) | - |
dc.subject.classification | Llet materna | - |
dc.subject.classification | COVID-19 | - |
dc.subject.classification | SARS-CoV-2 | - |
dc.subject.classification | Sistema immunitari | - |
dc.subject.other | Breast milk | - |
dc.subject.other | COVID-19 | - |
dc.subject.other | SARS-CoV-2 | - |
dc.subject.other | Immune system | - |
dc.title | SARS-CoV-2 RNA and antibody detection in human milk from a prospective multicenter study in Spain | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 721527 | - |
dc.date.updated | 2022-04-14T06:20:38Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Fisiologia) Articles publicats en revistes (BCNatal Fetal Medicine Research Center) |
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721527.pdf | 376.99 kB | Adobe PDF | View/Open |
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