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http://hdl.handle.net/2445/184973
Title: | GASVeM: A New Machine Learning Methodology for Multi-SNP Analysis of GWAS Data Based on Genetic Algorithms and Support Vector Machines |
Author: | Diez Diaz, Fidel Sanchez Lasheras, Fernando Moreno Aguado, Víctor Moratalla-Navarro, Ferran Molina de la Torre, Antonio José Martin Sanchez, Vicente |
Keywords: | Aprenentatge automàtic Algorismes genètics Genoma humà Machine learning Genetic algorithms Human genome |
Issue Date: | 18-Mar-2021 |
Publisher: | MDPI |
Abstract: | Genome-wide association studies (GWAS) are observational studies of a large set of genetic variants in an individual's sample in order to find if any of these variants are linked to a particular trait. In the last two decades, GWAS have contributed to several new discoveries in the field of genetics. This research presents a novel methodology to which GWAS can be applied to. It is mainly based on two machine learning methodologies, genetic algorithms and support vector machines. The database employed for the study consisted of information about 370,750 single-nucleotide polymorphisms belonging to 1076 cases of colorectal cancer and 973 controls. Ten pathways with different degrees of relationship with the trait under study were tested. The results obtained showed how the proposed methodology is able to detect relevant pathways for a certain trait: in this case, colorectal cancer. Keywords: machine learning; support vector machines; genetic algorithms; genome-wide association studies; single nucleotide polymorphism; pathways analysis |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/math9060654 |
It is part of: | Mathematics, 2021, vol. 9, num. 6 |
URI: | http://hdl.handle.net/2445/184973 |
Related resource: | https://doi.org/10.3390/math9060654 |
ISSN: | 2227-7390 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) |
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