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Title: | No Excess Mortality up to 10 Years in Early Stages of Breast Cancer in Women Adherent to Oral Endocrine Therapy: A Probabilistic Graphical Modeling Approach |
Author: | Clèries Soler, Ramon Buxó, Maria Vilardell, Mireia Ameijide, Alberto Martínez, José Miguel Font, Rebeca Marcos Gragera, Rafael Puigdemont, Montserrat Viñas, Gemma Carulla, Marià Espinàs Piñol, Josep Alfons Galceran, Jaume Izquierdo i Font, Àngel Xavier Borràs, Josep Maria |
Keywords: | Càncer de mama Endocrinologia Breast cancer Endocrinology |
Issue Date: | 18-Mar-2022 |
Publisher: | MDPI AG |
Abstract: | Breast cancer (BC) is globally the most frequent cancer in women. Adherence to endocrine therapy (ET) in hormone-receptor-positive BC patients is active and voluntary for the first five years after diagnosis. This study examines the impact of adherence to ET on 10-year excess mortality (EM) in patients diagnosed with Stages I to III BC (N = 2297). Since sample size is an issue for estimating age- and stage-specific survival indicators, we developed a method, ComSynSurData, for generating a large synthetic dataset (SynD) through probabilistic graphical modeling of the original cohort. We derived population-based survival indicators using a Bayesian relative survival model fitted to the SynD. Our modeling showed that hormone-receptor-positive BC patients diagnosed beyond 49 years of age at Stage I or beyond 59 years at Stage II do not have 10-year EM if they follow the prescribed ET regimen. This result calls for developing interventions to promote adherence to ET in patients with hormone receptor-positive BC and in turn improving cancer survival. The presented methodology here demonstrates the potential use of probabilistic graphical modeling for generating reliable synthetic datasets for validating population-based survival indicators when sample size is an issue. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijerph19063605 |
It is part of: | International Journal of Environmental Research and Public Health, 2022, vol. 19, num. 6 |
URI: | http://hdl.handle.net/2445/185037 |
Related resource: | https://doi.org/10.3390/ijerph19063605 |
ISSN: | 1660-4601 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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ijerph-19-03605.pdf | 1.93 MB | Adobe PDF | View/Open |
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