Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/185143
Title: | Lithium therapy and weight change in people with bipolar disorder: A systematic review and meta-analysis |
Author: | Gomes da Costa, Susana Marx, Wolfgang Corponi, Filippo Anmella, Gerard Murru, Andrea Pons Cabrera, Maria Teresa Giménez Palomo, Anna Gutiérrez Arango, Felipe Llach, Cristian Fico, Giovanna Kotzalidis, Georgios D. Verdolini, Norma Valentí Ribas, Marc Berk, Michael Vieta i Pascual, Eduard, 1963- Pacchiarotti, Isabella |
Keywords: | Trastorn bipolar Liti Psiquiatria Neurociència afectiva Depressió psíquica Manic-depressive illness Lithium Psychiatry Affective neuroscience Mental depression |
Issue Date: | 13-Jul-2021 |
Publisher: | Elsevier |
Abstract: | Lithium remains the gold standard maintenance treatment for Bipolar Disorder (BD). However, weight gain is a side effect of increasing relevance due to its metabolic implications. We conducted a systematic review and metaanalysis aimed at summarizing evidence on the use of lithium and weight change in BD. We followed the PRISMA methodology, searching Pubmed, Scopus and Web of Science. From 1003 screened references, 20 studies were included in the systematic review and 9 included in the meta-analysis. In line with the studies included in the systematic review, the meta-analysis revealed that weight gain with lithium was not significant, noting a weight increase of 0.462 Kg (p = 0158). A shorter duration of treatment was significantly associated with more weight gain. Compared to placebo, there were no significant differences in weight gain. Weight gain was significantly lower with lithium than with active comparators. This work reveals a low impact of lithium on weight change, especially compared to some of the most widely used active comparators. Our results could impact clinical decisions. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.neubiorev.2021.07.011 |
It is part of: | Neuroscience and Biobehavioral Reviews, 2021, vol. 134, p. 104266 |
URI: | http://hdl.handle.net/2445/185143 |
Related resource: | https://doi.org/10.1016/j.neubiorev.2021.07.011 |
ISSN: | 0149-7634 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
714447.pdf | 2.88 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License