Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/185147
Title: | Cognitive clusters in first-episode psychosis |
Author: | Amoretti Guadall, Silvia Rabelo da Ponte, Francisco Diego Rosa, Adriane Ribeiro Mezquida Mateos, Gisela Sánchez-Torres, Ana M. Fraguas, David Cabrera Llorca, Bibiana Lobo, Antonio González-Pinto, Ana Pina Camacho, Laura Corripio, Iluminada Vieta i Pascual, Eduard, 1963- Torrent, Carla Serna Gómez, Elena de la Bergé, Daniel Bioque Alcázar, Miquel Garriga, Marina Serra Navarro, Maria Cuesta, Manuel J. Bernardo Arroyo, Miquel |
Keywords: | Cognició Psicosi Trastorns de la cognició Neuropsicologia Cognition Psychoses Cognition disorders Neuropsychology |
Issue Date: | 1-Sep-2021 |
Publisher: | Elsevier B.V. |
Abstract: | Impairments in a broad range of cognitive domains have been consistently reported in some individuals with first-episode psychosis (FEP). Cognitive deficits can be observed during the prodromal stage. However, the course of cognitive deficits is still unclear. The aim of this study was to identify cognitive subgroups over time and to compare their sociodemographic, clinical and functional profiles. A total of 114 patients with Schizophrenia Spectrum Disorders were included in the present study. We assessed subjects through psychiatric scales and eight neuropsychological tests at baseline and at two-year follow-up visit. We performed the Partition Around Medoids algorithm with all cognitive variables. Furthermore, we performed a logistic regression to identify the predictors related to the different cognitive clusters at follow-up. Two distinct subgroups were found: the first cluster characterized by cognitive impairment and a second cluster had relatively intact cognition in comparison with norms. Up to 54.7% of patients with cognitive deficits at baseline tended to improve during the first two years of treatment. Patients with intact cognition at follow-up had a higher socioeconomic status, later age of onset, lower negative symptoms and a higher cognitive reserve (CR) at baseline. CR and age of onset were the baseline variables that predicted cognitive impairment. This research allows us to obtain a better understanding of the heterogeneous profile of psychotic disorders. Identifying the characteristics of patients who will |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.schres.2021.08.021 |
It is part of: | Schizophrenia Research, 2021, vol. 237, p. 31-39 |
URI: | https://hdl.handle.net/2445/185147 |
Related resource: | https://doi.org/10.1016/j.schres.2021.08.021 |
ISSN: | 0920-9964 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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