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Title: Cognitive clusters in first-episode psychosis
Author: Amoretti Guadall, Silvia
Rabelo da Ponte, Francisco Diego
Rosa, Adriane Ribeiro
Mezquida Mateos, Gisela
Sánchez-Torres, Ana M.
Fraguas, David
Cabrera Llorca, Bibiana
Lobo, Antonio
González-Pinto, Ana
Pina Camacho, Laura
Corripio, Iluminada
Vieta i Pascual, Eduard, 1963-
Torrent, Carla
Serna Gómez, Elena de la
Bergé, Daniel
Bioque Alcázar, Miquel
Garriga, Marina
Serra Navarro, Maria
Cuesta, Manuel J.
Bernardo Arroyo, Miquel
Keywords: Cognició
Trastorns de la cognició
Cognition disorders
Issue Date: 1-Sep-2021
Publisher: Elsevier B.V.
Abstract: Impairments in a broad range of cognitive domains have been consistently reported in some individuals with first-episode psychosis (FEP). Cognitive deficits can be observed during the prodromal stage. However, the course of cognitive deficits is still unclear. The aim of this study was to identify cognitive subgroups over time and to compare their sociodemographic, clinical and functional profiles. A total of 114 patients with Schizophrenia Spectrum Disorders were included in the present study. We assessed subjects through psychiatric scales and eight neuropsychological tests at baseline and at two-year follow-up visit. We performed the Partition Around Medoids algorithm with all cognitive variables. Furthermore, we performed a logistic regression to identify the predictors related to the different cognitive clusters at follow-up. Two distinct subgroups were found: the first cluster characterized by cognitive impairment and a second cluster had relatively intact cognition in comparison with norms. Up to 54.7% of patients with cognitive deficits at baseline tended to improve during the first two years of treatment. Patients with intact cognition at follow-up had a higher socioeconomic status, later age of onset, lower negative symptoms and a higher cognitive reserve (CR) at baseline. CR and age of onset were the baseline variables that predicted cognitive impairment. This research allows us to obtain a better understanding of the heterogeneous profile of psychotic disorders. Identifying the characteristics of patients who will
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It is part of: Schizophrenia Research, 2021, vol. 237, p. 31-39
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ISSN: 0920-9964
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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