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http://hdl.handle.net/2445/185153
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DC Field | Value | Language |
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dc.contributor.author | Haddad Tovolli, Roberta | - |
dc.contributor.author | Ramírez, Sara | - |
dc.contributor.author | Muñoz-Moreno, Emma | - |
dc.contributor.author | Milà Guasch, Marià | - |
dc.contributor.author | Miquel Rio, Lluís | - |
dc.contributor.author | Pozo, Macarena | - |
dc.contributor.author | Chivite, Íñigo | - |
dc.contributor.author | Altirriba Gutiérrez, Jordi | - |
dc.contributor.author | Obri, Arnaud | - |
dc.contributor.author | Gomez Valades, Alicia G. | - |
dc.contributor.author | Toledo, Miriam | - |
dc.contributor.author | Eyre, Elena | - |
dc.contributor.author | Bortolozzi, Annalia | - |
dc.contributor.author | Valjent, Emmanuel | - |
dc.contributor.author | Soria, Guadalupe | - |
dc.contributor.author | Claret i Carles, Marc | - |
dc.date.accessioned | 2022-04-25T09:24:00Z | - |
dc.date.available | 2022-10-04T05:10:26Z | - |
dc.date.issued | 2022-04-04 | - |
dc.identifier.issn | 2522-5812 | - |
dc.identifier.uri | http://hdl.handle.net/2445/185153 | - |
dc.description.abstract | Preparation for motherhood requires a myriad of physiological and behavioural adjustments throughout gestation to provide an adequate environment for proper embryonic development1. Cravings for highly palatable foods are highly prevalent during pregnancy2 and contribute to the maintenance and development of gestational overweight or obesity3. However, the neurobiology underlying the distinct ingestive behaviours that result from craving specific foods remain unknown. Here we show that mice, similarly to humans, experience gestational food craving-like episodes. These episodes are associated with a brain connectivity reorganization that affects key components of the dopaminergic mesolimbic circuitry, which drives motivated appetitive behaviours and facilitates the perception of rewarding stimuli. Pregnancy engages a dynamic modulation of dopaminergic signalling through neurons expressing dopamine D2 receptors in the nucleus accumbens, which directly modulate food craving-like events. Importantly, persistent maternal food craving-like behaviour has long-lasting effects on the offspring, particularly in males, leading to glucose intolerance, increased body weight and increased susceptibility to develop eating disorders and anxiety-like behaviours during adulthood. Our results reveal the cognitively motivated nature of pregnancy food cravings and advocates for moderating emotional eating during gestation to prevent deterioration of the offspring's neuropsychological and metabolic health.© 2022. The Author(s), under exclusive licence to Springer Nature Limited. | ca |
dc.format.extent | 50 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.publisher | Nature Publishing Group | ca |
dc.relation.isformatof | Postprint del document publicat a: https://doi.org/10.1038/s42255-022-00557-1 | - |
dc.relation.ispartof | Nature Metabolism, 2022, vol. 4, p. 424–434 | - |
dc.relation.uri | https://doi.org/10.1038/s42255-022-00557-1 | - |
dc.rights | (c) Haddad Tovolli, Roberta et al, 2022 | - |
dc.source | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) | - |
dc.subject.classification | Nutrició en l'embaràs | - |
dc.subject.classification | Dopamina | - |
dc.subject.other | Nutrition in pregnancy | - |
dc.subject.other | Dopamine | - |
dc.title | Food craving-like episodes during pregnancy are mediated by accumbal dopaminergic circuits | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2022-04-22T08:31:50Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9306581 | - |
dc.identifier.pmid | 35379970 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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Haddad-Tovolli_Nat_Metab_final_repository_compressed.pdf | 4.1 MB | Adobe PDF | View/Open |
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