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http://hdl.handle.net/2445/185198
Title: | Angiocrine polyamines production regulates adiposity |
Author: | Monelli, Erika Villacampa, Pilar Zabala Letona, Amaia Martínez Romero, Anabel Llena, Judith Beiroa, Daniel Gouveia, Leonor Chivite, Iñigo Zagmutt Caroxa, Sebastián Gama-Perez, Pau Osorio Conles, Óscar Muixí, Laia Martínez-González, Ainara Castillo, Sandra D. Martín-Martín, Natalia Castel Morales, Pau Valcárcel-Jiménez, Lorea García-González, Irene Villena, Josep A. Fernández Ruiz, Sonia Serra i Cucurull, Dolors Herrero Rodríguez, Laura Benedito, Rui García-Roves, Pablo M. (Pablo Miguel) Vidal, Josep Cohen, Paul Nogueiras, Rubén Claret i Carles, Marc Carracedo, Arkaitz Graupera i Garcia-Milà, Mariona |
Keywords: | Teixit adipós Obesitat Angiogènesi Metabolisme Adipose tissues Obesity Neovascularization Metabolism |
Issue Date: | 2022 |
Publisher: | Nature Publishing Group |
Abstract: | Reciprocal interactions between endothelial cells (ECs) and adipocytes are fundamental to maintain white adipose tissue (WAT) homeostasis, as illustrated by the activation of angiogenesis upon WAT expansion, a process that is impaired in obesity. However, the molecular mechanisms underlying the crosstalk between ECs and adipocytes remain poorly understood. Here, we show that local production of polyamines in ECs stimulates adipocyte lipolysis and regulates WAT homeostasis in mice. We promote enhanced cell-autonomous angiogenesis by deleting Pten in the murine endothelium. Endothelial Pten loss leads to a WAT-selective phenotype, characterized by reduced body weight and adiposity in pathophysiological conditions. This phenotype stems from enhanced fatty acid β-oxidation in ECs concomitant with a paracrine lipolytic action on adipocytes, accounting for reduced adiposity. Combined analysis of murine models, isolated ECs and human specimens reveals that WAT lipolysis is mediated by mTORC1-dependent production of polyamines by ECs. Our results indicate that angiocrine metabolic signals are important for WAT homeostasis and organismal metabolism. |
Note: | Versió postprint del document publicat a: |
It is part of: | Nature Metabolism, 2022 |
URI: | http://hdl.handle.net/2445/185198 |
ISSN: | 2522-5812 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Fisiologia) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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