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http://hdl.handle.net/2445/185201
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DC Field | Value | Language |
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dc.contributor.author | Mao, Xiaoman | - |
dc.contributor.author | Calero Pérez, Pilar | - |
dc.contributor.author | Montpeyó, David | - |
dc.contributor.author | Bruna, Jordi | - |
dc.contributor.author | Yuste, Victor J. | - |
dc.contributor.author | Candiota, Ana Paula | - |
dc.contributor.author | Lorenzo, Julia | - |
dc.contributor.author | Novio, Fernando | - |
dc.contributor.author | Ruiz Molina, Daniel | - |
dc.date.accessioned | 2022-04-28T14:25:29Z | - |
dc.date.available | 2022-04-28T14:25:29Z | - |
dc.date.issued | 2022-04-05 | - |
dc.identifier.issn | 2079-4991 | - |
dc.identifier.uri | http://hdl.handle.net/2445/185201 | - |
dc.description.abstract | Cisplatin has been described as a potent anticancer agent for decades. However, in the case of glioblastomas, it is only considered a rescue treatment applied after the failure of second-line treatments. Herein, based on the versatility offered by coordination chemistry, we engineered nanoparticles by reaction of a platinum (IV) prodrug and iron metal ions showing in vitro dual pH- and redox-sensitivity, controlled release and comparable cytotoxicity to cisplatin against HeLa and GL261 cells. In vivo intranasal administration in orthotopic preclinical GL261 glioblastoma tumor-bearing mice demonstrated increased accumulation of platinum in tumors, leading in some cases to complete cure and prolonged survival of the tested cohort. This was corroborated by a magnetic resonance imaging follow-up, thus opening new opportunities for intranasal glioblastoma therapies while minimizing side effects. The findings derived from this research showed the potentiality of this approach as a novel therapy for glioblastoma treatment. | - |
dc.format.extent | 22 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/nano12071221 | - |
dc.relation.ispartof | Nanomaterials, 2022, vol. 12, num. 7 | - |
dc.relation.uri | https://doi.org/10.3390/nano12071221 | - |
dc.rights | cc by (c) Mao, Xiaoman et al, 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Glioma | - |
dc.subject.classification | Nanopartícules | - |
dc.subject.other | Gliomas | - |
dc.subject.other | Nanoparticles | - |
dc.title | Intranasal Administration of Catechol-Based Pt(IV) Coordination Polymer Nanoparticles for Glioblastoma Therapy | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-04-28T10:02:16Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 35407338 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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nanomaterials-12-01221-v2.pdf | 3.5 MB | Adobe PDF | View/Open |
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