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http://hdl.handle.net/2445/185209
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DC Field | Value | Language |
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dc.contributor.author | Marques-Feixa, Laia | - |
dc.contributor.author | Castro Quintas, Águeda | - |
dc.contributor.author | Palma-Gudiel, Helena | - |
dc.contributor.author | Romero, Soledad | - |
dc.contributor.author | Morer, Astrid | - |
dc.contributor.author | Rapado-Castro, Marta | - |
dc.contributor.author | Martín, María | - |
dc.contributor.author | Zorrilla, Iñaki | - |
dc.contributor.author | Blasco-Fontecilla, Hilario | - |
dc.contributor.author | Ramírez, Maite | - |
dc.contributor.author | Mayoral, María | - |
dc.contributor.author | Mendez, Iría | - |
dc.contributor.author | San Martín-Gonzalez, Nerea | - |
dc.contributor.author | Rodrigo-Yanguas María | - |
dc.contributor.author | Monteserín-García, José Luis | - |
dc.contributor.author | Fañanás Saura, Lourdes | - |
dc.contributor.author | EPI-Young Stress GROUP | - |
dc.date.accessioned | 2022-04-29T13:59:38Z | - |
dc.date.available | 2022-04-29T13:59:38Z | - |
dc.date.issued | 2022-04-12 | - |
dc.identifier.issn | 0889-1591 | - |
dc.identifier.uri | http://hdl.handle.net/2445/185209 | - |
dc.description.abstract | Background: Mucosal secretory immunoglobulin A (s-IgA) is an antibody protein-complex that plays a crucial role in immune first defense against infection. Although different immune biomarkers have been associated with stress-related psychopathology, s-IgA remains poorly studied, especially in youth. Objectives: The present study investigated how s-IgA behaves in front of acute psychosocial stress in children and adolescents, including possible variability associated with developmental stage and history of childhood maltreatment (CM). Methods: 94 children and adolescents from 7 to 17 years (54 with a current psychiatric diagnostic and 40 healthy controls) drawn from a larger Spanish study were explored (EPI-Young Stress Project). To assess biological reactivity, participants provided five saliva samples during an acute laboratory-based psychosocial stressor, the Trier Social Stress Test for Children (TSST-C). Samples were assayed for s-IgA, as well as for cortisol. Pubertal development was ascertained by Tanner stage and CM following TASSCV criteria. Results: We observed s-IgA fluctuations throughout the stressor, indicating the validity of TSST-C to stimulate s-IgA secretion (F(4,199) = 6.200, p <.001). Although s-IgA trajectories followed a reactivity and recovery pattern in adolescents, children exhibited no s-IgA response when faced with stress (F(4,197) = 3.406, p =.010). An interaction was found between s-IgA and CM (F(4,203) = 2.643, p =.035). Interestingly, an interaction between developmental stage, CM history and s-IgA reactivity was identified (F(12,343) = 2.036, p =.017); while children non-exposed to maltreatment exhibited no s-IgA changes to acute stress, children with a history of CM showed a similar response to adolescents, increasing their s-IgA levels after the psychosocial stressor. Conclusion: Acute psychosocial stress stimulates s-IgA secretion, but only after puberty. However, children with a history of maltreatment exhibited a response resembling that of adolescents, suggesting an early maturation of the immune system. Further studies are needed to clarify the validity of s-IgA as an acute stress biomarker, including additional measures during stress exposure. Keywords: Acute stress; Adolescents; Childhood maltreatment; Children; Developmental stage; TSST-C; secretory Immunoglobulin A (s-IgA). | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.bbi.2022.04.010 | - |
dc.relation.ispartof | Brain, Behavior, and Immunity, 2022, vol. 103, p. 122-129 | - |
dc.relation.uri | https://doi.org/10.1016/j.bbi.2022.04.010 | - |
dc.rights | cc-by-nc-nd (c) Marques-Feixa, Laia et al., 2022 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.source | Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals) | - |
dc.subject.classification | Infants | - |
dc.subject.classification | Adolescents | - |
dc.subject.classification | Maltractament infantil | - |
dc.subject.classification | Tests psicològics | - |
dc.subject.classification | Immunoglobulina A | - |
dc.subject.other | Children | - |
dc.subject.other | Teenagers | - |
dc.subject.other | Child abuse | - |
dc.subject.other | Psychological tests | - |
dc.subject.other | Immunoglobulin A | - |
dc.title | Secretory immunoglobulin A (s-IgA) reactivity to acute psychosocial stress in children and adolescents: The influence of pubertal development and history of maltreatment. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 723194 | - |
dc.date.updated | 2022-04-29T13:59:39Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals) |
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