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DC Field | Value | Language |
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dc.contributor.author | Fico, Giovanna | - |
dc.contributor.author | Anmella, Gerard | - |
dc.contributor.author | Gómez Ramiro, Marta | - |
dc.contributor.author | Miquel, Carlota de | - |
dc.contributor.author | Hidalgo Mazzei, Diego | - |
dc.contributor.author | Manchia, Mirko | - |
dc.contributor.author | Alda, Martin | - |
dc.contributor.author | González-Pinto, Ana | - |
dc.contributor.author | Carvalho, André F. | - |
dc.contributor.author | Vieta i Pascual, Eduard, 1963- | - |
dc.contributor.author | Murru, Andrea | - |
dc.date.accessioned | 2022-04-27T13:57:59Z | - |
dc.date.available | 2022-04-27T13:57:59Z | - |
dc.date.issued | 2021-11-01 | - |
dc.identifier.issn | 0165-0327 | - |
dc.identifier.uri | http://hdl.handle.net/2445/185217 | - |
dc.description.abstract | Background: We primarily aimed to explore the associations between duration of untreated illness (DUI), treatment response, and functioning in a cohort of patients with bipolar disorder (BD). Methods: 261 participants with BD were recruited. DUI was defined as months from the first affective episode to the start of a mood-stabilizer. The functioning assessment short test (FAST) scores and treatment response scores for lithium, valproate, or lamotrigine according to the Alda Scale Total Score (TS) were compared between patients with short (<24 months) or long DUI. Differences in FAST scores among good (GR; TS≥7), poor (PR; TS=2-6), or non-responders (NR; TS<2) to each mood-stabilizer were analyzed. Linear regression was computed using the FAST global score as the dependent variable. Results: DUI and FAST scores showed no statistically significant correlation. Patients with a longer DUI showed poorer response to lithium (Z=-3.196; p<0.001), but not to valproate or lamotrigine. Response to lithium (β=-1.814; p<0.001), number of hospitalizations (β=0.237; p<0.001), and illness duration (β=0.160; p=0.028) were associated with FAST total scores. GR to lithium was associated with better global functioning compared to PR or NR [H=27.631; p<0.001]. Limitations: The retrospective design could expose our data to a recall bias. Also, only few patients were on valproate or lamotrigine treatment. Conclusions: Poor functioning in BD could be the result of multiple affective relapses, rather than a direct effect of DUI. A timely diagnosis with subsequent effective prophylactic treatment, such as lithium, may prevent poor functional outcomes in real-world patients with BD. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.jad.2021.07.062 | - |
dc.relation.ispartof | Journal of Affective Disorders, 2021, vol. 294, p. 513-520 | - |
dc.relation.uri | https://doi.org/10.1016/j.jad.2021.07.062 | - |
dc.rights | cc-by (c) Fico, Giovanna et al, 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Trastorn bipolar | - |
dc.subject.classification | Cognició | - |
dc.subject.classification | Psicodiagnòstic | - |
dc.subject.classification | Trastorns afectius | - |
dc.subject.other | Manic-depressive illness | - |
dc.subject.other | Cognition | - |
dc.subject.other | Psychodiagnostics | - |
dc.subject.other | Affective disorders | - |
dc.title | Duration of untreated illness and bipolar disorder: time for a new definition? Results from a cross-sectional study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 714456 | - |
dc.date.updated | 2022-04-27T13:57:59Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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