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Title: Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort
Author: Cairat, Manon
Rinaldi, Sabina
Navionis, Anne-Sophie
Romieu, Isabelle
Biessy, Carine
Viallon, Vivian
Olsen, Anja
Tjønneland, Anne
Fournier, Agnès
Severi, Gianluca
Kvaskoff, Marina
Fortner, Renée T.
Kaaks, Rudolf
Aleksandrova, Krasimira
Schulze, Matthias B.
Masala, Giovanna
Tumino, Rosario
Sieri, Sabina
Grasso, Chiara
Mattiello, Amalia
Gram, Inger T.
Olsen, Karina Standahl
Agudo, Antonio
Amiano Etxezarreta, Pilar
Sánchez, Maria Jose
Santiuste, Carmen
Barricarte, Aurelio
Monninkhof, Evelyn
Hiensch, Anouk E.
Muller, David
Merritt, Melissa A.
Travis, Ruth C.
Weiderpass, Elisabete
Gunter, Marc J.
Dossus, Laure
Keywords: Marcadors bioquímics
Càncer de mama
Biochemical markers
Breast cancer
Issue Date: 18-Apr-2022
Publisher: Springer Science and Business Media
Abstract: Background Inflammation has been hypothesized to play a role in the development and progression of breast cancer and might differently impact breast cancer risk among pre and postmenopausal women. We performed a nested case-control study to examine whether pre-diagnostic circulating concentrations of adiponectin, leptin, c-reactive protein (CRP), tumour necrosis factor-alpha, interferon-gamma and 6 interleukins were associated with breast cancer risk, overall and by menopausal status. Methods Pre-diagnostic levels of inflammatory biomarkers were measured in plasma from 1558 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We used conditional logistic regression to estimate the odds ratios (ORs) of breast cancer at blood collection, per one standard deviation increase in biomarker concentration. Results Cases were diagnosed at a mean age of 61.4 years on average 8.6 years after blood collection. No statistically significant association was observed between inflammatory markers and breast cancer risk overall. In premenopausal women, borderline significant inverse associations were observed for leptin, leptin-to-adiponectin ratio and CRP [OR= 0.89 (0.77-1.03), OR= 0.88 (0.76-1.01) and OR= 0.87 (0.75-1.01), respectively] while positive associations were observed among postmenopausal women [OR= 1.16 (1.05-1.29), OR= 1.11 (1.01-1.23), OR= 1.10 (0.99-1.22), respectively]. Adjustment for BMI strengthened the estimates in premenopausal women [leptin: OR = 0.83 (0.68-1.00), leptin-to-adiponectin ratio: OR = 0.80 (0.66-0.97), CRP: OR = 0.85 (0.72-1.00)] but attenuated the estimates in postmenopausal women [leptin: OR = 1.09 (0.96-1.24), leptin-to-adiponectin ratio: OR = 1.02 (0.89-1.16), CRP: OR = 1.04 (0.92-1.16)]. Conclusions Associations between CRP, leptin and leptin-to-adiponectin ratio with breast cancer risk may represent the dual effect of obesity by menopausal status although this deserves further investigation.
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It is part of: BMC Medicine, 2022
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ISSN: 1741-7015
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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