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http://hdl.handle.net/2445/185358
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DC Field | Value | Language |
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dc.contributor.author | Sánchez Benavides, Gonzalo | - |
dc.contributor.author | Salvadó, Gemma | - |
dc.contributor.author | Arenaza Urquijo, Eider M. | - |
dc.contributor.author | Grau Rivera, Oriol | - |
dc.contributor.author | Suárez Calvet, Marc | - |
dc.contributor.author | Milà Alomà, Marta | - |
dc.contributor.author | González de Echávarri, José M. | - |
dc.contributor.author | Minguillon, Carolina | - |
dc.contributor.author | Crous Bou, Marta | - |
dc.contributor.author | Niñerola Baizán, Aida | - |
dc.contributor.author | Perissinotti, Andrés | - |
dc.contributor.author | Gispert, Juan Domingo | - |
dc.contributor.author | Molinuevo, José Luis | - |
dc.contributor.author | ALFA Study | - |
dc.date.accessioned | 2022-05-04T14:35:49Z | - |
dc.date.available | 2022-05-04T14:35:49Z | - |
dc.date.issued | 2020-11-11 | - |
dc.identifier.issn | 2352-8729 | - |
dc.identifier.uri | http://hdl.handle.net/2445/185358 | - |
dc.description.abstract | Introduction: Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) outcome in cognitively unimpaired middle-aged individuals. Methods: A total of 261 participants from the ALFA+ study underwent [18F]flutemetamol PET and Subjective Cognitive Decline Questionnaire (SCD-Q) concurrently, and 3 years before scan. We used logistic regressions to evaluate the ability of SCD-Q scores (self and informant) to predict Aβ PET visual read, and repeated analysis of variance to assess whether changes in SCD-Q scores relate to Aβ status. Results: Self-perception of decline in memory (odds ratio [OR] = 1.2), and informant perception of executive decline (OR = 1.6), increased the probability of a positive scan. Informant reports 3 years before scanning predicted Aβ PET outcome. Longitudinal increase of self-reported executive decline was predictive of Aβ in women (P = .003). Discussion: Subjective reports of cognitive decline are useful to predict Aβ and may improve recruitment strategies. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Alzheimer's Association | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1002/dad2.12127 | - |
dc.relation.ispartof | Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) , 2020, vol. 12, num. 1 | - |
dc.relation.uri | https://doi.org/10.1002/dad2.12127 | - |
dc.rights | cc-by-nc (c) Sánchez Benavides, Gonzalo et al., 2020 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Malaltia d'Alzheimer | - |
dc.subject.classification | Amiloïdosi | - |
dc.subject.classification | Trastorns de la cognició | - |
dc.subject.classification | Símptomes | - |
dc.subject.classification | Diagnòstic | - |
dc.subject.other | Alzheimer's disease | - |
dc.subject.other | Amyloidosis | - |
dc.subject.other | Cognition disorders | - |
dc.subject.other | Symptoms | - |
dc.subject.other | Diagnosis | - |
dc.title | Quantitative informant- and self-reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4 | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 723097 | - |
dc.date.updated | 2022-05-04T14:35:49Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/752310/EU//BioALFA | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33204815 | - |
Appears in Collections: | Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Biomedicina) |
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723097.pdf | 375.88 kB | Adobe PDF | View/Open |
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