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http://hdl.handle.net/2445/185546
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DC Field | Value | Language |
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dc.contributor.author | Ferrer Fábrega, Joana | - |
dc.contributor.author | Folch i Puy, Emma | - |
dc.contributor.author | Lozano Salvatella, Juan José | - |
dc.contributor.author | Ventura Aguiar, Pedro | - |
dc.contributor.author | Cárdenas, Gabriel | - |
dc.contributor.author | Paredes, David | - |
dc.contributor.author | García Criado, Ángeles | - |
dc.contributor.author | Bombí, Josep Antoni | - |
dc.contributor.author | García Pérez, Rocío | - |
dc.contributor.author | López Boado, Miguel Ángel | - |
dc.contributor.author | Rull, Ramón | - |
dc.contributor.author | Esmatjes Mompó, Enric | - |
dc.contributor.author | Ricart Brulles, Ma. José | - |
dc.contributor.author | Diekmann, Fritz | - |
dc.contributor.author | Fondevila Campo, Constantino | - |
dc.contributor.author | Fernández Cruz, Laureano | - |
dc.contributor.author | Fuster Obregón, Josep | - |
dc.contributor.author | García-Valdecasas Salgado, Juan Carlos | - |
dc.date.accessioned | 2022-05-13T07:27:08Z | - |
dc.date.available | 2022-05-13T07:27:08Z | - |
dc.date.issued | 2022-03-28 | - |
dc.identifier.issn | 0934-0874 | - |
dc.identifier.uri | http://hdl.handle.net/2445/185546 | - |
dc.description.abstract | Due to the high vulnerability of the pancreas to ischemia-reperfusion injury, choices regarding preservation solution markedly affect pancreas transplant success. A retrospective single-center analysis of 380 pancreas transplants (2000-2019) was performed to correlate current preservation solutions with transplant outcomes. Early graft failure requiring transplantectomy within 30 days post-transplant occurred in 7.5% for University of Wisconsin (UW) group (n = 267), 10.8% of Celsior (CS) group (n = 83), 28.5% of Histidine-Tryptophan-Ketoglutarate (HTK) group (n = 7), and none for Institut Georges Lopez-1 (IGL-1) group (n = 23). The most common causes of technical failures in this cohort included abdominal hemorrhage (8.4%); graft pancreatitis (3.7%); fluid collections (2.6%); intestinal complications (6.6%); and vascular thrombosis (20.5%). Although IGL-1 solution provided lower surgical complication rates, no significant differences were found between studied groups. Nevertheless, HTK solution was associated with elevated pancreatitis rates. The best graft survival was achieved at 1 year using UW and IGL-1, and at 3 and 5 years using IGL-1 (p = 0.017). There were no significant differences in patient survival after a median follow-up of 118.4 months. In this setting therefore, IGL-1solution appears promising for perfusion and organ preservation in clinical pancreas transplantation, compared to other commonly used solutions. Keywords: pancreas transplantation, graft survival, preservation solution, ischemia-reperfusion, pancreatitis, | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/ti.2022.10419 | - |
dc.relation.ispartof | Transplant International, 2022, vol. 35, num. 10419 | - |
dc.relation.uri | https://doi.org/10.3389/ti.2022.10419 | - |
dc.rights | cc-by (c) Ferrer Fábrega, Joana et al., 2022 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Trasplantament d'òrgans | - |
dc.subject.classification | Conservació d'òrgans | - |
dc.subject.classification | Pàncrees | - |
dc.subject.other | Transplantation of organs | - |
dc.subject.other | Preservation of organs | - |
dc.subject.other | Pancreas | - |
dc.title | Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 722524 | - |
dc.date.updated | 2022-05-13T07:27:08Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9307854 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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722524.pdf | 2 MB | Adobe PDF | View/Open |
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