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http://hdl.handle.net/2445/185581
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DC Field | Value | Language |
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dc.contributor.author | Encinas, Cristina | - |
dc.contributor.author | Hernandez Rivas, José Ángel | - |
dc.contributor.author | Oriol, Albert | - |
dc.contributor.author | Rosiñol, Laura | - |
dc.contributor.author | Blanchard, María Jesús | - |
dc.contributor.author | Bellón, José María | - |
dc.contributor.author | García Sanz, Ramón | - |
dc.contributor.author | Rubia, Javier de la | - |
dc.contributor.author | López de la Guía, Ana | - |
dc.contributor.author | Jímenez Ubieto, Ana | - |
dc.contributor.author | Jarque, Isidro | - |
dc.contributor.author | Iñigo, Belén | - |
dc.contributor.author | Dourdil, Victoria | - |
dc.contributor.author | Arriba, Felipe de | - |
dc.contributor.author | Cuéllar Pérez-Ávila, Clara | - |
dc.contributor.author | Gonzalez, Yolanda | - |
dc.contributor.author | Hernández, Miguel Teodoro | - |
dc.contributor.author | Bargay, Joan | - |
dc.contributor.author | Granell, Miguel | - |
dc.contributor.author | Rodríguez Otero, Paula | - |
dc.contributor.author | Silvent, Maialen | - |
dc.contributor.author | Cabrera, Carmen | - |
dc.contributor.author | Rios, Rafael | - |
dc.contributor.author | Alegre, Adrián | - |
dc.contributor.author | Gironella, Mercedes | - |
dc.contributor.author | Gonzalez, Marta Sonia | - |
dc.contributor.author | Sureda, Anna | - |
dc.contributor.author | Sampol, Antonia | - |
dc.contributor.author | Ocio, Enrique M. | - |
dc.contributor.author | Krsnik, Isabel | - |
dc.contributor.author | García, Antonio | - |
dc.contributor.author | García Mateo, Aránzazu | - |
dc.contributor.author | Soler, Joan Alfons | - |
dc.contributor.author | Martín, Jesús | - |
dc.contributor.author | Arguiñano Pérez, José Mª | - |
dc.contributor.author | Mateos, María Victoria | - |
dc.contributor.author | Bladé, J. (Joan) | - |
dc.contributor.author | San Miguel, Jesús F. | - |
dc.contributor.author | Lahuerta, Juan José | - |
dc.contributor.author | Martínez López, Joaquín | - |
dc.contributor.author | Gem/pethema (Grupo Español de Mieloma/Programa para el estudio de la terapéutica en hemopatías malignas) Cooperative Study Group | - |
dc.date.accessioned | 2022-05-13T08:36:08Z | - |
dc.date.available | 2022-05-13T08:36:08Z | - |
dc.date.issued | 2022-04-01 | - |
dc.identifier.issn | 2044-5385 | - |
dc.identifier.uri | http://hdl.handle.net/2445/185581 | - |
dc.description.abstract | Infections remain a common complication in patients with multiple myeloma (MM) and are associated with morbidity and mortality. A risk score to predict the probability of early severe infection could help to identify the patients that would benefit from preventive measures. We undertook a post hoc analysis of infections in four clinical trials from the Spanish Myeloma Group, involving a total of 1347 patients (847 transplant candidates). Regarding the GEM2010 > 65 trial, antibiotic prophylaxis was mandatory, so we excluded it from the final analysis. The incidence of severe infection episodes within the first 6 months was 13.8%, and majority of the patients experiencing the first episode before 4 months (11.1%). 1.2% of patients died because of infections within the first 6 months (1% before 4 months). Variables associated with increased risk of severe infection in the first 4 months included serum albumin <= 30 g/L, ECOG > 1, male sex, and non-IgA type MM. A simple risk score with these variables facilitated the identification of three risk groups with different probabilities of severe infection within the first 4 months: low-risk (score 0-2) 8.2%; intermediate-risk (score 3) 19.2%; and high-risk (score 4) 28.3%. Patients with intermediate/high risk could be candidates for prophylactic antibiotic therapies. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Science and Business Media LLC | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41408-022-00652-2 | - |
dc.relation.ispartof | Blood Cancer Journal, 2022, vol. 12, num. 4 | - |
dc.relation.uri | https://doi.org/10.1038/s41408-022-00652-2 | - |
dc.rights | cc by (c) Encinas, Cristina et al, 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Mieloma múltiple | - |
dc.subject.classification | Antibiòtics | - |
dc.subject.other | Multiple myeloma | - |
dc.subject.other | Antibiotics | - |
dc.title | A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-05-12T10:23:23Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 35440057 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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s41408-022-00652-2.pdf | 1.16 MB | Adobe PDF | View/Open |
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