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http://hdl.handle.net/2445/185649
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DC Field | Value | Language |
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dc.contributor.author | Carbajosa Dalmau, José | - |
dc.contributor.author | Cosín-Sales, Juan | - |
dc.contributor.author | Pérez-Durá, Maria José | - |
dc.contributor.author | Noceda, José | - |
dc.contributor.author | Urtubia-Palacios, Amós | - |
dc.contributor.author | Hernández-Sori, Néstor | - |
dc.contributor.author | Peiró-Gómez, Ana | - |
dc.contributor.author | Jacob, Javier | - |
dc.contributor.author | Llorens, Pere | - |
dc.contributor.author | Ruescas-Gómez, Luis | - |
dc.contributor.author | Martín-Martinez, Alfonso | - |
dc.date.accessioned | 2022-05-16T17:37:52Z | - |
dc.date.available | 2022-05-16T17:37:52Z | - |
dc.date.issued | 2017-12-01 | - |
dc.identifier.issn | 1137-6821 | - |
dc.identifier.uri | http://hdl.handle.net/2445/185649 | - |
dc.description.abstract | Objectives: To study the effectiveness and safety of vernakalant for restoration of sinus rhythm in patients with atrial fibrillation (AF) in routine hospital emergency department care, and to evaluate factors associated with a more effective response. Material and methods: Prospective multicenter cohort study enrolling consecutive patients who were administered vernakalant for medical cardioversion of AF between September 2014 through March 2016 in 5 hospitals in the Spanish autonomous community of Valencia. Results: We studied 165 cases. The median (interquartile range) was 68 years (56-77) years. Cardioversion with vernakalant was effective in 77.6% (95% CI, 71.1%-84%). The median time to conversion was 8 ( 6-12) minutes after a first dose and 34 (22-62) minutes after a second dose. A prior history of cardiac insufficiency was nonsignificantly less common in patients who converted with vernakalant (6.3%) than in those who did not (18.9%) (adjusted odds ratio [OR], 0.45 [95% CI, 0.13-1.56]; P=.208). Having no prior history of AF was nonsignificantly related to greater effectiveness (in 54.7% vs in 35.1% with prior AF). Duration less than 12 hours was significantly associated with greater effectiveness (83.6% vs 59.5%; adjusted OR, 2.76 [95% CI, 1.12-6.80]; P=.028). Adverse events were reported for 30 patients. None of the events had clinically important consequences, and in only 2 cases (1.2%) was it necessary to suspend treatment. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Saned | - |
dc.relation.isformatof | Reproducció del document publicat a: https://pubmed.ncbi.nlm.nih.gov/29188914/ | - |
dc.relation.ispartof | Emergencias, 2017, vol. 29, num. 6, p. 397-402 | - |
dc.rights | (c) Saned, 2017 | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Fibril·lació auricular | - |
dc.subject.classification | Serveis d'urgències mèdiques | - |
dc.subject.classification | Medicaments cardiovasculars | - |
dc.subject.other | Atrial fibrillation | - |
dc.subject.other | Emergency medical services | - |
dc.subject.other | Cardiovascular agents | - |
dc.title | Vernakalant in hospital emergency practice: safety and effectiveness | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 708468 | - |
dc.date.updated | 2022-05-16T17:37:52Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29188914 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) |
Files in This Item:
File | Description | Size | Format | |
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708468.pdf | 154.11 kB | Adobe PDF | View/Open |
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