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Title: TRPV2: A Key Player in Myelination Disorders of the Central Nervous System
Author: Enrich Bengoa, Jennifer
Manich Raventós, Gemma
Valente, Tony
Sanchez Molina, Paula
Almolda, Beatriz
Solà i Subirana, Carme
Saura Martí, Josep
González, Berta
Castellano, Bernardo
Perálvarez Marín, Alex
Keywords: Malalties del sistema nerviós central
Estrès oxidatiu
Esclerosi múltiple
Canals iònics
Central nervous system diseases
Myelin sheath
Oxidative stress
Multiple sclerosis
Ion channels
Issue Date: 25-Mar-2022
Publisher: MDPI
Abstract: Transient potential receptor vanilloid 2 (TRPV2) is widely expressed through the nervous system and specifically found in neuronal subpopulations and some glial cells. TRPV2 is known to be sensitized by methionine oxidation, which results from inflammation. Here we aim to characterize the expression and regulation of TRPV2 in myelination pathologies, such as hypomyelination and demyelination. We validated the interaction between TRPV2 and its putative interactor Opalin, an oligodendrocyte marker, in mixed glial cultures under pro- and anti-inflammatory conditions. Then, we characterized TRPV2 time-course expression in experimental animal models of hypomyelination (jimpy mice) and de-/remyelination (cuprizone intoxication and experimental autoimmune encephalomyelitis (EAE)). TRPV2 showed upregulation associated with remyelination, inflammation in cuprizone and EAE models, and downregulation in hypomyelinated jimpy mice. TRPV2 expression was altered in human samples of multiple sclerosis (MS) patients. Additionally, we analyzed the expression of methionine sulfoxide reductase A (MSRA), an enzyme that reduces oxidated methionines in TRPV2, which we found increased in inflammatory conditions. These results suggest that TRPV2 may be a key player in myelination in accordance with the recapitulation hypothesis, and that it may become an interesting clinical target in the treatment of demyelination disorders.
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It is part of: International Journal of Molecular Sciences, 2022, vol. 23, num. 7, p. 3617
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ISSN: 1661-6596
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Biomedicina)

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