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Title: | Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome |
Author: | Díaz-López, Andrés Paz Graniel, Indira Ruiz, Verónica Toledo Atucha, Estefanía Becerra-Tomás, Nerea Corella Piquer, Dolores Castañer, Olga Martínez, J. Alfredo, 1957- Alonso-Gómez, Ángel M. Wärnberg, Julia Vioque, Jesús Romaguera, Dora López Miranda, José Estruch Riba, Ramon Tinahones, Francisco J. Lapetra, José Serra Majem, Lluís Bueno Cavanillas, Aurora Tur, Josep A. Martín Sánchez, Vicente Pintó Sala, Xavier Delgado-Rodríguez, Miguel Matía Martín, Pilar Vidal i Cortada, Josep Vázquez, Clotilde Daimiel, Lidia Villa, T.F. Ros Rahola, Emilio Eguaras, Sonia Babio, Nancy Sorlí, José V. Goday Arnó, Albert Abete, Itziar Tojal Sierra, Lucas Barón-López, Francisco Javier Torres-Collado, Laura Morey, Marga Garcia-Rios, Antonio Casas Rodríguez, Rosa M. Bernal-López, Maria Rosa Santos Lozano, José Manuel Navarro, Adela González, José I. Zomeño, María Dolores Zulet, M. Angeles Vaquero Luna, Jessica Ramallal, Raul Fitó Colomer, Montserrat Salas Salvadó, Jordi |
Keywords: | Cafeïna Cafè (Beguda) Síndrome metabòlica Malalties del ronyó Caffeine Coffee drink Metabolic syndrome Kidney diseases |
Issue Date: | 22-Apr-2021 |
Publisher: | Nature Publishing Group |
Abstract: | It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and 1-year changes in glomerular filtration rate (eGFR) in a large Spanish cohort of overweight/obese elderly with metabolic syndrome (MetS). This prospective analysis includes 5851 overweight/obese adults (55-75 years) with MetS from the PREDIMED-Plus study. We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes. Caffeinated coffee (> 2 cups/day) and tea (at least 1 cup/day) drinkers had 0.88 and 0.93 mL/min/1.73 m2 greater eGFR decrease respectively, compared to those with less than 1 cup/day of coffee consumption or non-tea drinkers. Furthermore, caffeinated coffee consumption of > 2 cups/day was associated with 1.19-fold increased risk of rapid eGFR decline > 3 mL/min/1.73 m2 (95% CI 1.01-1.41). Similarly, individuals in the highest (median, 51.2 mg/day) tertile of caffeine intake had a 0.87 mL/min/1.73 m2 greater eGFR decrease. Decaffeinated coffee was not associated with eGFR changes. In conclusion, higher consumption of caffeinated coffee, tea, and caffeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-88028-7 |
It is part of: | Scientific Reports, 2021, vol. 11, num. 1, p. 8719 |
URI: | http://hdl.handle.net/2445/185792 |
Related resource: | https://doi.org/10.1038/s41598-021-88028-7 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (Ciències Clíniques) Publicacions de projectes de recerca finançats per la UE |
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