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Title: Increased Circulating Levels of Growth Differentiation Factor 15 in Association with Metabolic Disorders in People Living with HIV Receiving Combined Antiretroviral Therapy
Author: Domingo, Pere (Domingo Pedrol)
Mateo, María Gracia
Villarroya i Terrade, Joan
Cereijo Téllez, Rubén
Torres, Ferran
Domingo i Pedrol, Joan Carles
Campderrós, Laura
Gallego-Escuredo, José M.
Gutierrez, María del Mar
Mur, Isabel
Corbacho, Noemí
Vidal, Francesc
Villarroya i Gombau, Francesc
Giralt i Oms, Marta
Keywords: Resistència a la insulina
Síndrome metabòlica
Persones seropositives
Insulin resistance
Metabolic syndrome
HIV-positive persons
Issue Date: 22-Jan-2022
Publisher: MDPI
Abstract: Objective: People living with HIV (PLWH) have an increased cardiovascular risk (CVR) owing to dyslipidemia, insulin resistance, metabolic syndrome, and HIV/combination antiretroviral therapy (cART)-associated lipodystrophy (HALS). Atherosclerosis and inflammation are related to growth differentiation factor-15 (GDF15). The relationship between metabolic disturbances, HALS, and CVR with GDF15 in PLWH is not known. Research design and methods: Circulating GDF15 levels in 152 PLWH (with HALS = 60, without HALS = 43, cART-naïve = 49) and 34 healthy controls were assessed in a cross-sectional study. Correlations with lipids, glucose homeostasis, fat distribution, and CVR were explored. Results: PLWH had increased circulating GDF15 levels relative to controls. The increase was the largest in cART-treated PLWH. Age, homeostatic model assessment of insulin resistance 1 (HOMA1-IR), HALS, dyslipidemia, C-reactive protein, and CVR estimated with the Framingham score correlated with GDF15 levels. The GDF15-Framingham correlation was lost after age adjustment. No correlation was found between GDF15 and the D:A:D Data Collection on Adverse Effects of Anti-HIV Drugs (D:A:D) score estimated CVR. CVR independent predictors were patient group (naïve, HALS−, and HALS+) and cumulated protease inhibitor or nucleoside reverse transcriptase inhibitor exposure. Conclusions: PLWH, especially when cART-treated, has increased GDF15 levels this increase is associated with dyslipidemia, insulin resistance, metabolic syndrome, HALS, and inflammation-related parameters. GDF15 is unassociated with CVR when age-adjusted.
Note: Reproducció del document publicat a:
It is part of: Journal of Clinical Medicine, 2022, vol. 11, num. 3, p. 1-13
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ISSN: 2077-0383
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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