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http://hdl.handle.net/2445/185982
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DC Field | Value | Language |
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dc.contributor.author | Esperatti, Mariano | - |
dc.contributor.author | Busico, Marina | - |
dc.contributor.author | Fuentes, Nora Angélica | - |
dc.contributor.author | Gallardo, Adrian | - |
dc.contributor.author | Osatnik, Javier | - |
dc.contributor.author | Vitali, Alejandra | - |
dc.contributor.author | Wasinger, Elizabeth Gisele | - |
dc.contributor.author | Olmos, Matías | - |
dc.contributor.author | Quintana, Jorgelina | - |
dc.contributor.author | Saavedra, Santiago Nicolas | - |
dc.contributor.author | Lagazio, Ana Inés | - |
dc.contributor.author | Andrada, Facundo Juan | - |
dc.contributor.author | Kakisu, Hiromi | - |
dc.contributor.author | Esteban Romano, Nahuel | - |
dc.contributor.author | Matarrese, Agustin | - |
dc.contributor.author | Mogadouro, Mariela Adriana | - |
dc.contributor.author | Mast, Giuliana | - |
dc.contributor.author | Navarro Moreno, Claudia | - |
dc.contributor.author | Rebaza Niquin, Greta Dennise | - |
dc.contributor.author | Barbaresi, Veronica | - |
dc.contributor.author | Bruhn Cruz, Alejandro | - |
dc.contributor.author | Ferreyro, Bruno Leonel | - |
dc.contributor.author | Torres Martí, Antoni | - |
dc.contributor.author | Argentine Collaborative Group on High Flow and Pro | - |
dc.date.accessioned | 2022-05-24T15:28:26Z | - |
dc.date.available | 2022-05-24T15:28:26Z | - |
dc.date.issued | 2022-01-07 | - |
dc.identifier.issn | 1364-8535 | - |
dc.identifier.uri | http://hdl.handle.net/2445/185982 | - |
dc.description.abstract | Abstract Background: In patients with COVID-19-related acute respiratory failure (ARF), awake prone positioning (AW-PP) reduces the need for intubation in patients treated with high-fow nasal oxygen (HFNO). However, the efects of different exposure times on clinical outcomes remain unclear. We evaluated the efect of AW-PP on the risk of endotracheal intubation and in-hospital mortality in patients with COVID-19-related ARF treated with HFNO and analyzed the efects of diferent exposure times to AW-PP. Methods: This multicenter prospective cohort study in six ICUs of 6 centers in Argentine consecutively included patients>18 years of age with confrmed COVID-19-related ARF requiring HFNO from June 2020 to January 2021. In the primary analysis, the main exposure was awake prone positioning for at least 6 h/day, compared to non-prone positioning (NON-PP). In the sensitivity analysis, exposure was based on the number of hours receiving AW-PP. Inverse probability weighting-propensity score (IPW-PS) was used to adjust the conditional probability of treatment assignment. The primary outcome was endotracheal intubation (ETI); and the secondary outcome was hospital mortality. Results: During the study period, 580 patients were screened and 335 were included; 187 (56%) tolerated AW-PP for [median (p25-75)] 12 (9-16) h/day and 148 (44%) served as controls. The IPW-propensity analysis showed standardized diferences<0.1 in all the variables assessed. After adjusting for other confounders, the OR (95% CI) for ETI in the AW-PP group was 0.36 (0.2-0.7), with a progressive reduction in OR as the exposure to AW-PP increased. The adjusted | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/s13054-021-03881-2 | - |
dc.relation.ispartof | Critical Care, 2022, vol. 26, num. 1, p. 16-25 | - |
dc.relation.uri | https://doi.org/10.1186/s13054-021-03881-2 | - |
dc.rights | cc-by (c) Esperatti, Mariano et al., 2022 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | COVID-19 | - |
dc.subject.classification | Insuficiència respiratòria | - |
dc.subject.classification | Intubació | - |
dc.subject.classification | Posicions dels malalts | - |
dc.subject.classification | Oxigenoteràpia | - |
dc.subject.classification | Mortalitat | - |
dc.subject.other | COVID-19 | - |
dc.subject.other | Respiratory insufficiency | - |
dc.subject.other | Intubation | - |
dc.subject.other | Positioning of patients | - |
dc.subject.other | Oxygen therapy | - |
dc.subject.other | Mortality | - |
dc.title | Impact of exposure time in awake prone positioning on clinical outcomes of patients with COVID-19-related acute respiratory failure treated with high-flow nasal oxygen: a multicenter cohort study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 722047 | - |
dc.date.updated | 2022-05-24T15:28:26Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34996496 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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