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http://hdl.handle.net/2445/185989
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DC Field | Value | Language |
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dc.contributor.author | Mellado Artigas, Ricard | - |
dc.contributor.author | Ferreyro, Bruno Leonel | - |
dc.contributor.author | Angriman, Federico | - |
dc.contributor.author | Hernández Sanz, María L. | - |
dc.contributor.author | Arruti, Egoitz | - |
dc.contributor.author | Torres Martí, Antoni | - |
dc.contributor.author | Villar, Jesús | - |
dc.contributor.author | Brochard, Laurent | - |
dc.contributor.author | Ferrando, Carlos | - |
dc.contributor.author | COVID-19 Spanish ICU Network | - |
dc.date.accessioned | 2022-05-24T18:12:50Z | - |
dc.date.available | 2022-05-24T18:12:50Z | - |
dc.date.issued | 2021-02-11 | - |
dc.identifier.issn | 1364-8535 | - |
dc.identifier.uri | http://hdl.handle.net/2445/185989 | - |
dc.description.abstract | Purpose: Whether the use of high-flow nasal oxygen in adult patients with COVID-19 associated acute respiratory failure improves clinically relevant outcomes remains unclear. We thus sought to assess the effect of high-flow nasal oxygen on ventilator-free days, compared to early initiation of invasive mechanical ventilation, on adult patients with COVID-19. Methods: We conducted a multicentre cohort study using a prospectively collected database of patients with COVID-19 associated acute respiratory failure admitted to 36 Spanish and Andorran intensive care units (ICUs). Main exposure was the use of high-flow nasal oxygen (conservative group), while early invasive mechanical ventilation (within the first day of ICU admission; early intubation group) served as the comparator. The primary outcome was ventilator-free days at 28 days. ICU length of stay and all-cause in-hospital mortality served as secondary outcomes. We used propensity score matching to adjust for measured confounding. Results: Out of 468 eligible patients, a total of 122 matched patients were included in the present analysis (61 for each group). When compared to early intubation, the use of high-flow nasal oxygen was associated with an increase in ventilator-free days (mean difference: 8.0 days; 95% confidence interval (CI): 4.4 to 11.7 days) and a reduction in ICU length of stay (mean difference: - 8.2 days; 95% CI - 12.7 to - 3.6 days). No difference was observed in all-cause in-hospital mortality between groups (odds ratio: 0.64; 95% CI: 0.25 to 1.64). Conclusions: The use of high-flow nasal oxygen upon ICU admission in adult patients with COVID-19 related acute hypoxemic respiratory failure may lead to an increase in ventilator-free days and a reduction in ICU length of stay, when compared to early initiation of invasive mechanical ventilation. Future studies should confirm our findings. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/s13054-021-03469-w | - |
dc.relation.ispartof | Critical Care, 2021, vol. 25, num. 1, p. 58 | - |
dc.relation.uri | https://doi.org/10.1186/s13054-021-03469-w | - |
dc.rights | cc-by (c) Mellado Artigas, Ricard et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | COVID-19 | - |
dc.subject.classification | Malalties de l'aparell respiratori | - |
dc.subject.classification | Oxigenoteràpia | - |
dc.subject.classification | Respiració artificial | - |
dc.subject.other | COVID-19 | - |
dc.subject.other | Respiratory diseases | - |
dc.subject.other | Oxygen therapy | - |
dc.subject.other | Artificial respiration | - |
dc.title | High-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 711829 | - |
dc.date.updated | 2022-05-24T18:12:50Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33573680 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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711829.pdf | 1.11 MB | Adobe PDF | View/Open |
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