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http://hdl.handle.net/2445/186014
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DC Field | Value | Language |
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dc.contributor.author | Vico Rivero, Tania | - |
dc.contributor.author | Youssif, Catrin | - |
dc.contributor.author | Zare, Fathema | - |
dc.contributor.author | Comalada Vila, Mònica | - |
dc.contributor.author | Sebastian, Carlos | - |
dc.contributor.author | Lloberas Cavero, Jorge | - |
dc.contributor.author | Celada Cotarelo, Antonio | - |
dc.date.accessioned | 2022-05-25T13:06:52Z | - |
dc.date.available | 2022-05-25T13:06:52Z | - |
dc.date.issued | 2022-03-01 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | http://hdl.handle.net/2445/186014 | - |
dc.description.abstract | At inflammatory loci, pro-inflammatory activation of macrophages produces large amounts of reactive oxygen species (ROS) that induce DNA breaks and apoptosis. Given that M-CSF and GM-CSF induce two different pathways in macrophages, one for proliferation and the other for survival, in this study we wanted to determine if these growth factors are able to protect against the DNA damage produced during macrophage activation. In macrophages treated with DNA-damaging agents we found that GM-CSF protects better against DNA damage than M-CSF. Treatment with GM-CSF resulted in faster recovery of DNA damage than treatment with M-CSF. The number of apoptotic cells induced after DNA damage was higher in the presence of M-CSF. Protection against DNA damage by GM-CSF is not related to its higher capacity to induce proliferation. GM-CSF induces differentiation markers such as CD11c and MHCII, as well as the pro-survival Bcl-2A1 protein, which make macrophages more resistant to DNA damage. | - |
dc.format.extent | 20 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/cells11060935 | - |
dc.relation.ispartof | Cells, 2022, vol. 11, num. 6, p. 1-20 | - |
dc.relation.uri | https://doi.org/10.3390/cells11060935 | - |
dc.rights | cc-by (c) Vico, Tania et al., 2022 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) | - |
dc.subject.classification | Macròfags | - |
dc.subject.classification | Factors de creixement | - |
dc.subject.other | Macrophages | - |
dc.subject.other | Growth factors | - |
dc.title | GM-CSF Protects Macrophages from DNA Damage by Inducing Differentiation | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 722318 | - |
dc.date.updated | 2022-05-25T13:06:52Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) |
Files in This Item:
File | Description | Size | Format | |
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722318.pdf | 3.7 MB | Adobe PDF | View/Open |
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