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dc.contributor.authorGarcía Pérez, Isabel-
dc.contributor.authorMolsosa-Solanas, Anna-
dc.contributor.authorPerelló-Amorós, Miquel-
dc.contributor.authorSarropoulou, Elena-
dc.contributor.authorBlasco Mínguez, Josefina-
dc.contributor.authorGutiérrez Fruitós, Joaquín-
dc.contributor.authorGarcía de la Serrana Castillo, Daniel-
dc.description.abstractLong non-coding RNAs (lncRNAs) are an emerging group of ncRNAs that can modulate gene expression at the transcriptional or translational levels. In the present work, previously published transcriptomic data were used to identify lncRNAs expressed in gilthead sea bream skeletal muscle, and their transcription levels were studied under different physiological conditions. Two hundred and ninety lncRNAs were identified and, based on transcriptomic differences between juveniles and adults, a total of seven lncRNAs showed potential to be important for muscle development. Our data suggest that the downregulation of most of the studied lncRNAs might be linked to increased myoblast proliferation, while their upregulation might be necessary for differentiation. However, with these data, as it is not possible to propose a formal mechanism to explain their effect, bioinformatic analysis suggests two possible mechanisms. First, the lncRNAs may act as sponges of myoblast proliferation inducers microRNAs (miRNAs) such as miR-206, miR-208, and miR-133 (binding energy MEF < −25.0 kcal). Secondly, lncRNA20194 had a strong predicted interaction towards the myod1 mRNA (ndG = −0.17) that, based on the positive correlation between the two genes, might promote its function. Our study represents the first characterization of lncRNAs in gilthead sea bream fast skeletal muscle and provides evidence regarding their involvement in muscle development.-
dc.format.extent22 p.-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofCells, 2022, vol. 11, num. 3, p. 1-22-
dc.rightscc-by (c) García-Pérez, Isabel et al., 2022-
dc.sourceArticles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)-
dc.subject.otherSparus aurata-
dc.titleThe Emerging Role of Long Non-Coding RNAs in Development and Function of Gilthead Sea Bream (Sparus aurata) Fast Skeletal Muscle-
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

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