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DC Field | Value | Language |
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dc.contributor.author | López Delgado, Juan Carlos | - |
dc.contributor.author | Grau Carmona, Teodoro | - |
dc.contributor.author | Trujillano Cabello, Javier | - |
dc.contributor.author | García Fuentes, Carlos | - |
dc.contributor.author | Mor Marco, Esther | - |
dc.contributor.author | Bordeje Laguna, Maria Luisa | - |
dc.contributor.author | Portugal Rodriguez, Esther | - |
dc.contributor.author | Lorencio-cardenas, Carol | - |
dc.contributor.author | Vera Artazcoz, Paula | - |
dc.contributor.author | Macaya Redin, Laura | - |
dc.contributor.author | Martinez Carmona, Juan Francisco | - |
dc.contributor.author | Mateu Campos, Lidón | - |
dc.contributor.author | Gero Escapa, Maria | - |
dc.contributor.author | Gastaldo Simeon, Rosa | - |
dc.contributor.author | Vila García, Belen | - |
dc.contributor.author | Flordelis Lasierra, José Luis | - |
dc.contributor.author | Montejo Gonzalez, Juan Carlos | - |
dc.contributor.author | Servia Goixart, Lluís | - |
dc.contributor.author | ENPIC Study Investigators | - |
dc.date.accessioned | 2022-05-27T08:05:20Z | - |
dc.date.available | 2022-05-27T08:05:20Z | - |
dc.date.issued | 2022-05-01 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | http://hdl.handle.net/2445/186097 | - |
dc.description.abstract | Background: The present research aimed to evaluate the effect on outcomes of immunonutrition (IMN) enteral formulas during the intensive care unit (ICU) stay. Methods: A multicenter prospective observational study was performed. Patient characteristics, disease severity, nutritional status, type of nutritional therapy and outcomes, and laboratory parameters were collected in a database. Statistical differences were analyzed according to the administration of IMN or other types of enteral formulas. Results: In total, 406 patients were included in the analysis, of whom 15.02% (61) received IMN. Univariate analysis showed that patients treated with IMN formulas received higher mean caloric and protein intake, and better 28-day survival (85.2% vs. 73.3%; p = 0.014. Unadjusted Hazard Ratio (HR): 0.15; 95% CI (Confidence Interval): 0.06-0.36; p < 0.001). Once adjusted for confounding factors, multivariate analysis showed a lower need for vasopressor support (OR: 0.49; 95% CI: 0.26-0.91; p = 0.023) and continuous renal replacement therapies (OR: 0.13; 95% CI: 0.01-0.65; p = 0.049) in those patients who received IMN formulas, independently of the severity of the disease. IMN use was also associated with higher protein intake during the administration of nutritional therapy (OR: 6.23; 95% CI: 2.59-15.54; p < 0.001), regardless of the type of patient. No differences were found in the laboratory parameters, except for a trend toward lower triglyceride levels (HR: 0.97; 95% CI: 0.95-0.99; p = 0.045). Conclusion: The use of IMN formulas may be associated with better outcomes (i.e., lower need for vasopressors and continuous renal replacement), together with a trend toward higher protein enteral delivery during the ICU stay. These findings may ultimately be related to their modulating effect on the inflammatory response in the critically ill. NCT Registry: 03634943. | - |
dc.format.extent | 16 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/nu14091904 | - |
dc.relation.ispartof | Nutrients, 2022, vol. 14, num. 9 | - |
dc.relation.uri | https://doi.org/10.3390/nu14091904 | - |
dc.rights | cc by (c) Lopez Delgado, Juan Carlos et al, 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Medicina d'urgència | - |
dc.subject.classification | Alimentació enteral | - |
dc.subject.other | Emergency medicine | - |
dc.subject.other | Enteral feeding | - |
dc.title | The Effect of Enteral Immunonutrition in the Intensive Care Unit: Does It Impact on Outcomes? | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-05-26T10:09:33Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 35565870 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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nutrients-14-01904-v2.pdf | 1.42 MB | Adobe PDF | View/Open |
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