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DC Field | Value | Language |
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dc.contributor.author | Wang, Sophia S. | - |
dc.contributor.author | Vajdic, Claire M. | - |
dc.contributor.author | Linet, Martha S. | - |
dc.contributor.author | Slager, Susan L. | - |
dc.contributor.author | Voutsinas, Jenna | - |
dc.contributor.author | Nieters, Alexandra | - |
dc.contributor.author | Casabonne, Delphine | - |
dc.contributor.author | Cerhan, James R. | - |
dc.contributor.author | Cozen, Wendy | - |
dc.contributor.author | Alarcón, Graciela | - |
dc.contributor.author | Martínez Maza, Otoniel | - |
dc.contributor.author | Brown, Elizabeth E. | - |
dc.contributor.author | Bracci, Paige M. | - |
dc.contributor.author | Turner, Jennifer | - |
dc.contributor.author | Hjalgrim, Henrik | - |
dc.contributor.author | Bhatti, Parveen | - |
dc.contributor.author | Zhang, Yawei | - |
dc.contributor.author | Birmann, Brenda M. | - |
dc.contributor.author | Flowers, Christopher R. | - |
dc.contributor.author | Paltiel, Ora | - |
dc.contributor.author | Holly, Elizabeth A. | - |
dc.contributor.author | Kane, Eleanor | - |
dc.contributor.author | Weisenburger, Dennis D. | - |
dc.contributor.author | Maynadié, Marc | - |
dc.contributor.author | Cocco, Pierluigi | - |
dc.contributor.author | Foretova, Lenka | - |
dc.contributor.author | Breen, Elizabeth Crabb | - |
dc.contributor.author | Lan, Qing | - |
dc.contributor.author | Brooks-Wilson, Angela | - |
dc.contributor.author | Roos, Anneclaire J. de | - |
dc.contributor.author | Smith, Martyn T. | - |
dc.contributor.author | Roman, Eve | - |
dc.contributor.author | Boffetta, Paolo | - |
dc.contributor.author | Kricker, Anne | - |
dc.contributor.author | Zheng, Tongzhang | - |
dc.contributor.author | Skibola, Christine F. | - |
dc.contributor.author | Clavel, Jacqueline | - |
dc.contributor.author | Monnereau, Alain | - |
dc.contributor.author | Chanock, Stephen J. | - |
dc.contributor.author | Rothman, Nathaniel | - |
dc.contributor.author | Benavente, Yolanda | - |
dc.contributor.author | Hartge, Patricia | - |
dc.contributor.author | Smedby, Karin E. | - |
dc.date.accessioned | 2022-06-01T13:52:25Z | - |
dc.date.available | 2022-06-01T13:52:25Z | - |
dc.date.issued | 2022-02-24 | - |
dc.identifier.issn | 1538-7755 | - |
dc.identifier.uri | http://hdl.handle.net/2445/186151 | - |
dc.description.abstract | Background: A previous International Lymphoma Epidemiology (InterLymph) Consortium evaluation of joint associations between five immune gene variants and autoimmune conditions reported interactions between B-cell response-mediated autoimmune conditions and the rs1800629 genotype on risk of B-cell non-Hodgkin lymphoma (NHL) subtypes. Here, we extend that evaluation using NHL subtype-specific polygenic risk scores (PRS) constructed from loci identified in genome-wide association studies of three common B-cell NHL subtypes. Methods: In a pooled analysis of NHL cases and controls of Caucasian descent from 14 participating InterLymph studies, we evaluated joint associations between B-cell-mediated autoimmune conditions and tertile (T) of PRS for risk of diffuse large B-cell lymphoma (DLBCL; n = 1,914), follicular lymphoma (n = 1,733), and marginal zone lymphoma (MZL; n = 407), using unconditional logistic regression. Results: We demonstrated a positive association of DLBCL PRS with DLBCL risk [T2 vs. T1: OR = 1.24; 95% confidence interval (CI), 1.08-1.43; T3 vs. T1: OR = 1.81; 95% CI, 1.59-2.07; P-trend (P-trend) < 0.0001]. DLBCL risk also increased with increasing PRS tertile among those with an autoimmune condition, being highest for those with a B-cell-mediated autoimmune condition anda T3 PRS [OR = 6.46 vs. no autoimmune condition anda T1 PRS, P-trend < 0.0001, P-interaction (P-interaction) = 0.49]. Follicular lymphoma and MZL risk demonstrated no evidence of joint associations or significant P-interaction. Conclusions: Our results suggest that PRS constructed from currently known subtype-specific loci may not necessarily capture biological pathways shared with autoimmune conditions. Impact: Targeted genetic (PRS) screening among population subsets with autoimmune conditions may offer opportunities for identifying those at highest risk for (and early detection from) DLBCL. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Association for Cancer Research (AACR) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1158/1055-9965.EPI-21-0875 | - |
dc.relation.ispartof | Cancer Epidemiology, Biomarkers & Prevention, 2022, vol. 31, num. 5, p. 1103-1110 | - |
dc.relation.uri | https://doi.org/10.1158/1055-9965.EPI-21-0875 | - |
dc.rights | cc by-nc-nd (c) Wang, Sophia S. et al, 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Malalties autoimmunitàries | - |
dc.subject.classification | Genòmica | - |
dc.subject.other | Autoimmune diseases | - |
dc.subject.other | Genomics | - |
dc.title | B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-06-01T07:28:00Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 35244686 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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