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Title: Circulating Sex Hormone Levels and Colon Cancer Risk in Men: A Nested Case-Control Study and Meta-analysis
Author: Harbs, Justin
Rinaldi, Sabina
Gicquiau, Audrey
Keski-Rahkonen, Pekka
Mori, Nagisa
Liu, Xijia
Kaaks, Rudolf
Katzke, Verena
Schulze, Matthias B.
Agnoli, Claudia
Tumino, Rosario
Bueno de Mesquita, Bas
Crous Bou, Marta
Sanchez, Maria José
Aizpurua, Amaia
Chirlaque López, María Dolores
Barricarte Gurrea, Aurelio
Travis, Ruth C.
Watts, Eleanor L.
Christakoudi, Sofia
Tsilidis, Konstantinos K.
Weiderpass, Elisabete
Gunter, Marc J.
Guelpen, Bethany van
Murphy, Neil
Harlid, Sophia
Keywords: Càncer colorectal
Hormones sexuals
Colorectal cancer
Sex hormones
Issue Date: 27-Jan-2022
Publisher: American Association for Cancer Research (AACR)
Abstract: Background: Endogenous sex hormones may contribute to higher colorectal cancer incidence rates in men compared with women, but despite an increased number of studies, clear evidence is lacking. Methods: We conducted a comprehensive nested case-control study of circulating concentrations of sex hormones, sex hormone precursors, and sex hormone binding globulin (SHBG) in relation to subsequent colon cancer risk in European men. Concentrations were measured using liquid LC/MS-MS in prospectively collected plasma samples from 690 cases and 690 matched controls from the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Northern Sweden Health and Disease Study (NSHDS) cohorts. Multivariable conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). In addition, we conducted a meta-analysis of previous studies on men. Results: Circulating levels of testosterone (OR, 0.68; 95% CI, 0.51-0.89) and SHBG (OR, 0.77; 95% CI, 0.62-0.96) were inversely associated with colon cancer risk. For free testosterone, there was a nonsignificant inverse association (OR, 0.83; 95% CI, 0.58-1.18). In a dose-response meta-analysis of endogenous sex hormone levels, inverse associations with colorectal/colon cancer risk were found for testosterone [relative risks (RR) per 100 ng/dL = 0.98; 95% CI, 0.96-1.00; I-2 = 22%] and free testosterone (RR per 1 ng/dL = 0.98; 95% CI, 0.95-1.00; I-2 = 0%). Conclusions: Our results provide suggestive evidence for the association between testosterone, SHBG, and male colon cancer development. Impact: Additional support for the involvement of sex hormones in male colon cancer.
Note: Reproducció del document publicat a:
It is part of: Cancer Epidemiology Biomarkers & Prevention, 2022, vol. 31, num. 4, p. 793-803
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ISSN: 1538-7755
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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