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Title: Immunoelectron microscopic localization of transforming growth factor alpha in rat colon
Author: Pérez Tomás, Ricardo E.
Culleré i Luengo, F. Xavier
Asbert i Alsina, Mònica
Díaz Ruiz, Carmen
Keywords: Còlon
Cicle cel·lular
Factors de creixement
Cell cycle
Growth factors
Issue Date: 1994
Publisher: BMJ Group
Abstract: Transforming growth factor alpha (TGF alpha) is a polypeptide, which binds to the epidermal growth factor receptor to carry out its function related to cell proliferation and differentiation. The ultrastructural localisation of TGF alpha was studied in both the proximal and the distal colon. The columnar cells, lining the surface epithelium of the proximal colon, showed a strong immunoreactivity in the polyribosomes and in the interdigitations of the lateral membrane. The columnar cells of the crypts and the goblet cells in both the proximal and the distal colon showed the immunostaining in the cis and trans cisternae of the Golgi apparatus. TGF alpha seems to be processed differently in the surface columnar cells and in the crypt columnar cells and goblet cells. Moreover, it probably has different roles in proliferation and differentiation.
Note: Reproducció digital del document publicat a:
It is part of: Gut, 1994, vol. 35, núm. 8, p. 1086-1089
Related resource:
ISSN: 0017-5749
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Biomedicina)

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