Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/186494
Title: | A Galactooligosaccharide Product Decreases the Rotavirus Infection in Suckling Rats |
Author: | Massot Cladera, Malen Rigo Adrover, Maria del Mar Herrero Rodríguez, Laura Franch i Masferrer, Àngels Castell, Margarida Vulevic, Jelena Pérez-Cano, Francisco J. Rodríguez Lagunas, María José |
Keywords: | Diarrea Prebiòtics Malalties intestinals Diarrhea Prebiotics Intestinal diseases |
Issue Date: | 18-May-2022 |
Publisher: | MDPI |
Abstract: | The leading cause of gastroenteritis among young children worldwide is the Group A rotaviruses (RV), which produce a wide range of symptoms, from a limited diarrhea to severe dehydration and even death. After an RV infection, immunity is not complete and less severe re-infections usually occur. These infections could be ameliorated by nutritional interventions with bioactive compounds, such as prebiotics. The aim of this research was to study the impact of a particular galactooligosaccharide (B-GOS) on the RV symptomatology and immune response during two consecutive infections. Lewis neonatal rats were inoculated with SA11 (first RV infection) on day 6 of life and with EDIM (second RV infection) on day 17 of life. B-GOS group was administered by oral gavage with a daily dose of B-GOS between days three to nine of life. Clinical and immunological variables were assessed during both infective processes. In the first infection, after the prebiotic intervention with B-GOS, a lower incidence, duration, and overall severity of the diarrhea (p < 0.05) was observed. In addition, it improved another severity indicator, the fecal weight output, during the diarrhea period (p < 0.05). The second RV infection failed in provoking diarrhea in the groups studied. The immune response during first infection with SA11 was not affected by B-GOS administration and had no impact on second infection, but the prebiotic intervention significantly increased IFN-γ and TNF-α intestinal production after the second infection (p < 0.05). In summary, B-GOS supplementation is able to reduce the incidence and severity of the RV-associated diarrhea and to influence the immune response against RV infections. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/cells11101669 |
It is part of: | Cells, 2022 |
URI: | http://hdl.handle.net/2445/186494 |
Related resource: | https://doi.org/10.3390/cells11101669 |
ISSN: | 2073-4409 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Fisiologia) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
723599.pdf | 2.48 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License