Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/186526
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pires da Rosa, Gilberto | - |
dc.contributor.author | Sousa Pinto, Bernardo | - |
dc.contributor.author | Ferreira, Ester | - |
dc.contributor.author | Araújo, Olga | - |
dc.contributor.author | Barilaro, Giuseppe | - |
dc.contributor.author | Bettencourt, Paulo | - |
dc.contributor.author | Cervera i Segura, Ricard, 1960- | - |
dc.contributor.author | Espinosa, Gerard | - |
dc.date.accessioned | 2022-06-09T17:00:56Z | - |
dc.date.available | 2022-06-09T17:00:56Z | - |
dc.date.issued | 2022-01-03 | - |
dc.identifier.issn | 1478-6362 | - |
dc.identifier.uri | http://hdl.handle.net/2445/186526 | - |
dc.description.abstract | Background: Seronegative antiphospholipid syndrome (SN-APS) is often defned as the presence of APS criteria manifestations, negative antiphospholipid antibodies (aPL), and coexistence of APS non-criteria manifestations. Nevertheless, the impact of these non-criteria features is still unclear. On a diferent note, the relevance of one single aPL positive determination in patients with APS manifestations is another domain with limited evidence. We aim to compare the course of SN-APS and single-positive aPL (SP-aPL) patients with that of individuals with APS manifesta‑ tions without non-criteria features/aPL positivity (controls). Methods: Retrospective analysis of patients with thrombosis/obstetric morbidity assessed in two European hospi‑ tals between 2005 and 2020. Patients were divided into SN-APS, SP-aPL, and control groups. Clinical characteristics, comorbidities, and therapies were compared. Results: A total of 82 patients were included in the SN-APS group, 88 in the SP-aPL group, and 185 in the control group. In Cox regression model, SN-APS displayed more thrombosis recurrence than controls (HR 3.8, 95% CI 2.2-6.5, p<0.001) even when adjusting for the presence of hereditary thrombophilia, systemic lupus erythematosus, or con‑ traceptive hormonal treatment. In SP-aPL, the diference in thrombosis recurrence did not reach statistical signifcance (p=0.078). Indefnite anticoagulation (p<0.001 and p=0.008, respectively) and vitamin K antagonist (VKA) use (p<0.001 in both cases) were more common in SN-APS/SP-aPL. Conclusion: SN-APS displayed more thrombosis recurrence, indefnite anticoagulation, and VKA use than controls without non-criteria manifestations. The presence of such features in patients with thrombosis and negative aPL may negatively impact their clinical course. Keywords: Antiphospholipid syndrome, Antiphospholipid antibodies, Seronegative, Single positive, Non-criteria manifestations | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/s13075-021-02702-9 | - |
dc.relation.ispartof | Arthritis Research & Therapy, 2022, vol. 24, num. 1, p. 9 | - |
dc.relation.uri | https://doi.org/10.1186/s13075-021-02702-9 | - |
dc.rights | cc-by (c) Pires da Rosa, Gilberto et al., 2022 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Malalties autoimmunitàries | - |
dc.subject.classification | Síndrome antifosfolipídica | - |
dc.subject.classification | Autoanticossos | - |
dc.subject.classification | Lupus eritematós | - |
dc.subject.classification | Embaràs | - |
dc.subject.other | Autoimmune diseases | - |
dc.subject.other | Antiphospholipid syndrome | - |
dc.subject.other | Autoantibodies | - |
dc.subject.other | Lupus erythematosus | - |
dc.subject.other | Pregnancy | - |
dc.title | The presence of non-criteria manifestations negatively affects the prognosis of seronegative antiphospholipid syndrome patients: a multicenter study. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 719910 | - |
dc.date.updated | 2022-06-09T17:00:56Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9295603 | - |
dc.identifier.pmid | 34980238 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
719910.pdf | 1.21 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License