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Title: Magnesium hydrogen breath test using end-expiratory sampling to assess achlorhydria in pernicious anaemia patients
Author: Humbert Yagüe, Pere
López de Soria, P.
Fernández Bañares, Fernando
Juncà i Piera, Jordi
Boix, J.
Planas Vilà, Ramon
Quer Boniquet, Joan Carles
Domenech, E.
Gassull, Miquel Àngel
Keywords: Anèmia perniciosa
Pernicious anemia
Issue Date: 1994
Publisher: BMJ Group
Abstract: A modified magnesium hydrogen breath test, using end expiratory breath sampling, is described to investigate achlorhydria. The efficacy of this test in the diagnostic investigation of pernicious anaemia was compared with that of serum pepsinogen I. Twenty one patients with pernicious anaemia--that is, patients with achlorhydria--and 22 with healed duodenal ulcer and normal chlorhydria were studied. Magnesium hydrogen breath test, serum pepsinogen I, serum gastrin, and standard gastric acid secretory tests were performed in all subjects. The mean (SEM) hydrogen peak value was lower in patients with pernicious anaemia than in the duodenal ulcer group (21.7 (1.9) v 71.3 (5.2) ppm; p = 0.00005). The hydrogen peak value had a 95.2% sensitivity and a 100% specificity to detect pentagastrin resistant achlorhydria. Mean serum pepsinogen I concentrations were also significantly lower in patients with pernicious anaemia than in the duodenal ulcer group (10.7 (2.7) v 123.6 (11.8) micrograms/l p = 0.00005). Sensitivity and specificity to detect pernicious anaemia were both 100% for pepsinogen I. It is concluded that this modified magnesium hydrogen breath test is a simple, noninvasive, cost effective, and accurate method to assess achlorhydria and may be useful in the diagnostic investigation of patients with suspected pernicious anaemia.
Note: Reproducció digital del document publicat a:
It is part of: Gut, 1994, vol. 35, núm. 9, p. 1205-1208
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ISSN: 0017-5749
Appears in Collections:Articles publicats en revistes (Medicina)

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