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DC Field | Value | Language |
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dc.contributor.author | Mas Stachurska, Aleksandra | - |
dc.contributor.author | Egea Guri, Gustavo | - |
dc.contributor.author | de Bruin-Bon, R | - |
dc.contributor.author | Rudenick, Paula | - |
dc.contributor.author | Sanchis Ruiz, Laura | - |
dc.contributor.author | Bouma, Berto J. | - |
dc.contributor.author | Mulder, Barbara J. | - |
dc.contributor.author | Bijnens, Bart | - |
dc.contributor.author | Sitges Carreño, Marta | - |
dc.date.accessioned | 2022-06-15T15:01:25Z | - |
dc.date.available | 2022-06-15T15:01:25Z | - |
dc.date.issued | 2021-08-04 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/186682 | - |
dc.description.abstract | The mechanisms leading to cardiac remodeling in Marfan syndrome (MFS) are a matter of debate since it could be either due to structural dysfunction of the myocardial extracellular matrix or to increased afterload caused by the dilated aorta. We aim to characterize the presence of abnormal myocardial function in MFS and to investigate its potential association with increased afterload. Aorta, left ventricle (LV) and the postsystolic thickening (PST) were analyzed in echocardiography in Fbn1C1039G/+ mice and in patients with MFS in comparison with wild type (WT) mice and healthy humans. PST was more frequent in MFS than in WT mice (p< 0.05). MFS mice with PST showed larger aorta than those without PST. Patients with MFS showed larger aorta, poorer LV function and a higher prevalence of PST (56%) than did the healthy controls (23%); p= 0.003. Blood pressure was similar. The higher prevalence of PST in an experimental murine model and in MFS patients, regardless of systemic arterial pressure, suggests an increased afterload on the LV myocardium. This fnding supports the use of PST as an indicator of myocardial damage and encourage searching for novel early preventive therapy | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-95263-5 | - |
dc.relation.ispartof | Scientific Reports, 2021, vol. 2021, p. 1-10 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-021-95263-5 | - |
dc.rights | cc-by (c) Mas-Stachurska, Aleksandra et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Miocardi | - |
dc.subject.classification | Ventricles cardíacs | - |
dc.subject.classification | Malalties de l'aorta | - |
dc.subject.other | Myocardium | - |
dc.subject.other | Ventricle of heart | - |
dc.subject.other | Aorta diseases | - |
dc.title | Postsystolic thickening is a potential new clinical sign of injured myocardium in marfan syndrome. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 718984 | - |
dc.date.updated | 2022-06-15T15:01:26Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34349174 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
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File | Description | Size | Format | |
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718984.pdf | 1.21 MB | Adobe PDF | View/Open |
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