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Title: | Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study |
Author: | Rouzé, Anahita Lemaitre, Elise Martin Loeches, Ignacio Povoa, Pedro Diaz, Emili Nyga, Rémy Torres Martí, Antoni Metzelard, Matthieu Du Cheyron, Damien Lambiotte, Fabien Tamion, Fabienne Labruyere, Marie Boulle Geronimi, Claire Luyt, Charles-Edouard Nyunga, Martine Pouly, Olivier Thille, Arnaud Wilfrid Megarbane, Bruno Saade, Anastasia Magira, Eleni Llitjos, Jean-François Ioannidou, Iliana Pierre, Alexandre Reignier, Jean Garot, Denis Kreitmann, Louis Baudel, Jean-Luc Voiriot, Guillaume Plantefeve, Gaëtan Morawiec, Elise Asfar, Pierre Boyer, Alexandre Mekontso-Dessap, Armand Makris, Demosthenes Vinsonneau, Christophe Floch, Pierre-Edouard Marois, Clémence Ceccato, Adrian Artigas, Antonio Gaudet, Alexandre |
Keywords: | COVID-19 Unitats de cures intensives Grip COVID-19 Intensive care units Influenza |
Issue Date: | 4-Jan-2022 |
Publisher: | BioMed Central |
Abstract: | Background: Recent multicenter studies identifed COVID-19 as a risk factor for invasive pulmonary aspergillosis (IPA). However, no large multicenter study has compared the incidence of IPA between COVID-19 and infuenza patients. Objectives: To determine the incidence of putative IPA in critically ill SARS-CoV-2 patients, compared with infuenza patients. Methods: This study was a planned ancillary analysis of the coVAPid multicenter retrospective European cohort. Con‑ secutive adult patients requiring invasive mechanical ventilation for>48 h for SARS-CoV-2 pneumonia or infuenza pneumonia were included. The 28-day cumulative incidence of putative IPA, based on Blot defnition, was the primary outcome. IPA incidence was estimated using the Kalbfeisch and Prentice method, considering extubation (dead or alive) within 28 days as competing event. Results: A total of 1047 patients were included (566 in the SARS-CoV-2 group and 481 in the infuenza group). The incidence of putative IPA was lower in SARS-CoV-2 pneumonia group (14, 2.5%) than in infuenza pneumonia group (29, 6%), adjusted cause-specifc hazard ratio (cHR) 3.29 (95% CI 1.53-7.02, p=0.0006). When putative IPA and Aspergillus respiratory tract colonization were combined, the incidence was also signifcantly lower in the SARS-CoV-2 group, as compared to infuenza group (4.1% vs. 10.2%), adjusted cHR 3.21 (95% CI 1.88-5.46, p<0.0001). In the whole |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/s13054-021-03874-1 |
It is part of: | Critical Care, 2022, vol. 26, num. 1, p. 11-24 |
URI: | http://hdl.handle.net/2445/186710 |
Related resource: | https://doi.org/10.1186/s13054-021-03874-1 |
ISSN: | 1364-8535 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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