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DC Field | Value | Language |
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dc.contributor.author | Beltrán Pávez, Carolina | - |
dc.contributor.author | Gutiérrez López, Miguel | - |
dc.contributor.author | Rubio Garrido, Marina | - |
dc.contributor.author | Valadés Alcaraz, Ana | - |
dc.contributor.author | Prieto, Luis | - |
dc.contributor.author | Ramos, José Tomas | - |
dc.contributor.author | Jiménez de Ory, Santiago | - |
dc.contributor.author | Navarro, Marisa | - |
dc.contributor.author | Díez-Romero, Cristina | - |
dc.contributor.author | Pulido, Federico | - |
dc.contributor.author | Valencia, Eulalia | - |
dc.contributor.author | Holguín, África | - |
dc.contributor.author | Noguera Julian, Antoni | - |
dc.date.accessioned | 2022-06-16T13:41:09Z | - |
dc.date.available | 2022-06-16T13:41:09Z | - |
dc.date.issued | 2020-10-09 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/186712 | - |
dc.description.abstract | The aim of this transversal study was to describe the virological and immunological features of HIV-infected youths transferred from pediatric to adult care units since 1997 vs. the non-transferred patients from the Madrid Cohort of HIV-infected children and adolescents in Spain. We included 106 non-transferred and 184 transferred patients under clinical follow-up in 17 public hospitals in Madrid by the end of December 2017. Virological and immunological outcomes were compared in transferred vs. non-transferred patients. ART drug resistance mutations and HIV-variants were analyzed in all subjects with available resistance pol genotypes and/or genotypic resistance profiles. Among the study cohort, 133 (72.3%) of 184 transferred and 75 (70.7%) of 106 non-transferred patients had available resistance genotypes. Most (88.9%) of transferred had ART experience at sampling. A third (33.3%) had had a triple-class experience. Acquired drug resistance (ADR) prevalence was significantly higher in pretreated transferred than non-transferred patients (71.8% vs. 44%; p = 0.0009), mainly to NRTI (72.8% vs. 31.1%; p < 0.0001) and PI (29.1% vs. 12%; p = 0.0262). HIV-1 non-B variants were less frequent in transferred vs. non-transferred (6.9% vs. 32%; p < 0.0001). In conclusion, the frequent resistant genotypes found in transferred youths justifies the reinforcement of HIV resistance monitoring after the transition to avoid future therapeutic failures. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-020-70861-x | - |
dc.relation.ispartof | Scientific Reports, 2020, vol. 10, num. 1, p. 16891 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-020-70861-x | - |
dc.rights | cc-by (c) Beltrán Pávez, Carolina et al., 2020 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Infeccions per VIH | - |
dc.subject.classification | Resistència als medicaments | - |
dc.subject.classification | Adolescents | - |
dc.subject.other | HIV infections | - |
dc.subject.other | Drug resistance | - |
dc.subject.other | Teenagers | - |
dc.title | Virological outcome among HIV infected patients transferred from pediatric care to adult units in Madrid, Spain (1997-2017) | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 717347 | - |
dc.date.updated | 2022-06-16T13:41:09Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33037235 | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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717347.pdf | 2.01 MB | Adobe PDF | View/Open |
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