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http://hdl.handle.net/2445/186713
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DC Field | Value | Language |
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dc.contributor.author | Carreras Badosa, Gemma | - |
dc.contributor.author | Gómez Vilarrubla, Ariadna | - |
dc.contributor.author | Mas Pares, Berta | - |
dc.contributor.author | Xargay i Torrent, Sílvia | - |
dc.contributor.author | Prats Puig, Anna | - |
dc.contributor.author | Puerto-Carranza, Elsa | - |
dc.contributor.author | de Zegher, Francis | - |
dc.contributor.author | Ibañez Toda, Lourdes | - |
dc.contributor.author | Bassols, Judit | - |
dc.contributor.author | López Bermejo, Abel | - |
dc.date.accessioned | 2022-06-16T14:04:42Z | - |
dc.date.available | 2022-06-16T14:04:42Z | - |
dc.date.issued | 2021-09-14 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/186713 | - |
dc.description.abstract | Both the innate and adaptive immune responses are deregulated in individuals with obesity and are key drivers of its associated metabolic alterations. Although the anti-inflammatory growth differentiation factor 15 (GDF-15) is a candidate protein against obesity, its mechanisms regulating the immune responses are not fully cleared. We examined whether GDF-15 was related to serum immunoglobulins in a children's cohort assessed longitudinally during childhood. Results showed that circulating GDF-15 positively associated with IgA (p < 0.002) and IgG (p < 0.001) levels and the IgA*IgG product (p < 0.001) in apparently healthy children at both baseline (age 9) and follow-up (age 13). The associations were readily observed in heavier children (those with BMI-SDS above the median) as well as in children with higher renal fat accumulation (those with renal fat-to-height ratio above the median) and remained significant after correcting for possible confounding variables. Serum GDF-15 levels accounted for up to 16% of the variance of follow-up IgG levels and up to 14% of the variance of follow-up IgA*IgG product. The longitudinal associations of the anti-inflammatory GDF-15 with IgA, IgG and the IgA*IgG product in children with higher BMI or higher renal fat accumulation suggest a role of GDF-15 in human obesity through the regulation of the immune adaptive system. | - |
dc.format.extent | 5 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-97386-1 | - |
dc.relation.ispartof | Scientific Reports, 2021, p. 18215-18215 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-021-97386-1 | - |
dc.rights | cc-by (c) Carreras Badosa, Gemma et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Teixit adipós | - |
dc.subject.classification | Adolescents | - |
dc.subject.classification | Obesitat | - |
dc.subject.classification | Ronyó | - |
dc.subject.classification | Immunoglobulina A | - |
dc.subject.other | Adipose tissues | - |
dc.subject.other | Teenagers | - |
dc.subject.other | Obesity | - |
dc.subject.other | Kidney | - |
dc.subject.other | Immunoglobulin A | - |
dc.title | Longitudinal association of the anti-inflammatory serum marker GDF-15 with serum IgA and IgG in apparently healthy children | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 719468 | - |
dc.date.updated | 2022-06-16T14:04:42Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34521901 | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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719468.pdf | 999.57 kB | Adobe PDF | View/Open |
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