Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/186886
Title: | Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease-A Retrospective, Case-Control Pilot Study. |
Author: | Masoller Casas, Narcís Gómez Roig, Maria Dolors Escobar Diaz, María C. Pérez Cruz, Míriam Arráez, Miguel Cascant Vilaplana, Mari Merce Albiach Delgado, Abel Kuligowski, Julia Vento, Máximo Gómez, Olga Sanchez de Toledo, Joan Camprubí Camprubí, Marta |
Keywords: | Fetus Malalties del cor Fetus Heart diseases |
Issue Date: | 31-Jan-2022 |
Publisher: | MDPI |
Abstract: | Fetuses with congenital heart disease (CHD) have circulatory changes that may lead to predictable blood flow disturbances that may affect normal brain development. Hypoxemia and hypoperfusion may alter the redox balance leading to oxidative stress (OS), that can be assessed measuring stable end-products. OS biomarkers (OSB) were measured in amniotic fluid in fetuses with (n = 41) and without CHD (n = 44) and analyzed according to aortic flow, expected cyanosis after birth, and a CHD classification derived from this. Birth head circumference (HC) was used as a neurodevelopment biomarker. CHD fetuses had higher levels of ortho-Tyrosine (o-Tyr) than controls (p = 0.0003). There were no differences in o-Tyr levels considering aortic flow obstruction (p = 0.617). Fetuses with expected extreme cyanosis presented the highest levels of o-Tyr (p = 0.003). Among groups of CHD, fetuses without aortic obstruction and extreme cyanosis had the highest levels of o-Tyr (p = 0.005). CHD patients had lower HC than controls (p = 0.023), without correlation with OSB. Patients with HC < 10th percentile, presented high levels of o-Tyr (p = 0.024). Fetuses with CHD showed increased OSB and lower HC when compared to controls, especially those with expected extreme cyanosis. Our results suggest that increased levels of OSB are more influenced by the effect of low oxygenation than by aortic flow obstruction. Future studies with larger sample size are needed to further investigate the role of OSB as an early predictor of neurodevelopmental problems in CHD survivors. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/antiox11020299 |
It is part of: | Antioxidants, 2022, vol. 11, num. 2 |
URI: | http://hdl.handle.net/2445/186886 |
Related resource: | https://doi.org/10.3390/antiox11020299 |
ISSN: | 2076-3921 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (BCNatal Fetal Medicine Research Center) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
20_Escobar-Diaz MC_2022.pdf | 2.37 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License