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dc.contributor.authorFernández de Gamarra-Oca L-
dc.contributor.authorZubiaurre Elorza, Leire-
dc.contributor.authorJunqué i Plaja, Carme, 1955--
dc.contributor.authorSolana Díaz, Elisabeth-
dc.contributor.authorSoria Pastor, Sara-
dc.contributor.authorVázquez, Elida-
dc.contributor.authorDelgado, Ignacio-
dc.contributor.authorMacaya Ruiz, Alfons-
dc.contributor.authorOjeda, Natalia-
dc.contributor.authorPoca, Maria A-
dc.description.abstractPreterm newborns with germinal matrix-intraventricular hemorrhage (GM-IVH) are at a higher risk of evidencing neurodevelopmental alterations. Present study aimed to explore the long-term efects that GM-IVH have on hippocampal subfelds, and their correlates with memory. The sample consisted of 58 participants, including 36 preterm-born (16 with GM-IVH and 20 without neonatal brain injury), and 22 full-term children aged between 6 and 15 years old. All participants underwent a cognitive assessment and magnetic resonance imaging study. GM-IVH children evidenced lower scores in Full Intelligence Quotient and memory measures compared to their low-risk preterm and full-term peers. High-risk preterm children with GM-IVH evidenced signifcantly lower total hippocampal volumes bilaterally and hippocampal subfeld volumes compared to both low-risk preterm and full-term groups. Finally, signifcant positive correlations between memory and hippocampal subfeld volumes were only found in preterm participants together; memory and the right CA-feld correlation remained signifcant after Bonferroni correction was applied (p= .002). In conclusion, memory alterations and both global and regional volumetric reductions in the hippocampus were found to be specifcally related to a preterm sample with GM-IVH. Nevertheless, results also suggest that prematurity per se has a long-lasting impact on the association between the right CA-feld volume and memory during childhood.-
dc.format.extent11 p.-
dc.publisherNature Publishing Group-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofScientific Reports, 2021, vol. 11, p. 2420-
dc.rightscc-by (c) Fernández de Gamarra-Oca L et al., 2021-
dc.subject.classificationMalalties cerebrals-
dc.subject.classificationDesenvolupament infantil-
dc.subject.classificationInfants prematurs-
dc.subject.classificationImatges per ressonància magnètica-
dc.subject.otherBrain diseases-
dc.subject.otherChild development-
dc.subject.otherPremature infants-
dc.subject.otherMagnetic resonance imaging-
dc.titleReduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix intraventricular hemorrhage.-
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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